哮喘联盟

   摘要
   背景：哮喘急性发作和其他呼吸道症状与接触污染空气有关。环境影响基因甲基化，因此假设哮喘对污染物的反应是通过基因甲基化介导的。
   材料与方法:主要研究空气颗粒物对支气管哮喘气道基因甲基化影响的可能性。对来自年龄标准化研究的141例受试者的甲基化队列数据进行检测。来自于一个中心的黑碳和硫酸情况被记录，平均30天统计每一门诊情况。对哮喘气道进行基因特异性甲基化分数统计，同时采用稀疏典型性相关分析法对哮喘气道甲基化和污染物的关系进行分析。
   结果：分析显示，哮喘气道甲基化模式与黑碳和硫酸暴露显著相关（P=0.05 vs P=0.02）。与这一相关性有关的某些特定基因已被确认。
   结论:结果提示，空气污染对哮喘和呼吸道反应的影响可能是通过基因甲基化介导的。
 

(刘国梁 审校)
Epigenomics. 2013 Apr;5(2):147-54. doi: 10.2217/epi.13.16.

 

Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway.
 

Sofer T, Baccarelli A, Cantone L, Coull B, Maity A, Lin X, Schwartz J.
 

Abstract
BACKGROUND: Asthma exacerbation and other respiratory symptoms are associated with exposure to air pollution. Since environment affects gene methylation, it is hypothesized that asthmatic responses to pollution are mediated through methylation.
MATERIALS & METHODS: We study the possibility that airborne particulate matter affects gene methylation in the asthma pathway. We measured methylation array data in clinic visits of 141 subjects from the Normative Aging Study. Black carbon and sulfate measures from a central monitoring site were recorded and 30-day averages were calculated for each clinic visit. Gene-specific methylation scores were calculated for the genes in the asthma pathway, and the association between the methylation in the asthma pathway and the pollution measures was analyzed using sparse Canonical Correlation Analysis.
RESULTS: The analysis found that exposures to black carbon and sulfate were significantly associated with the methylation pattern in the asthma pathway (p-values 0.05 and 0.02, accordingly). Specific genes that contributed to this association were identified.
CONCLUSION: These results suggest that the effect of air pollution on asthmatic and respiratory responses may be mediated through gene methylation.
 

Epigenomics. 2013 Apr;5(2):147-54. doi: 10.2217/epi.13.16.