哮喘联盟

   摘要
   背景：睫毛膏通常被用于上睫毛,其中所采用的胶水含有氨基丙烯酸酯，这一物质已知可导致职业性鼻炎（OR）和职业性哮喘（OA）。
   目的：报道一例同时罹患OA和OR的病例，以及另一例单纯OR，两例病例均由睫毛膏诱发。评估使用睫毛膏过程中的呼吸道暴露。方法：两例疑似OA和/或OR罹患这接受吸入激发试验， 包括对照激发试验和使用睫毛膏的模拟工作激发试验，分别予以24小时随访。睫毛膏激发试验中同时测定挥发性有机物（VOCs）含量。分析睫毛膏被中(甲基)丙烯酸酯含量。
   结果：两位均为美容专业人员，因工作关系常规每天使用数小时睫毛膏，均患有工作相关性鼻炎。病例1有较长时间睫毛膏相关工作史，同时有哮喘症状。两病例第一个睫毛膏激发试验均为阴性，但第二项试验均中表现出OR反应阳性。病例1还有迟发性哮喘反应。睫毛膏激发试验中，检测到低于诱发阈值的VOC，氰基乙酸乙酯（ECA）浓度为0.4mg/m3。对睫毛膏的化学分析发现ECA是其主要成分。.
   结论：使用含小剂量氨基丙烯酸酯的睫毛膏可诱发OA和OR。
 

(刘国梁 审校)
Occup Med (Lond). 2013 Apr 3. [Epub ahead of print]

 

Occupational asthma and rhinitis caused by cyanoacrylate-based eyelash extension glues.
 

Lindström I, Suojalehto H, Henriks-Eckerman ML, Suuronen K.
 

Abstract
BACKGROUND：Eyelash extensions are applied on top of customers' lashes using instant glue containing cyano acrylate, known to cause occupational rhinitis (OR) and occupational asthma (OA). The number of beauty professionals applying these extensions is increasing due to their popularity. Aims: To report on a case of OA with OR and a case of OR attributable to lash extension glue and to evaluate respiratory exposure in lash extension work.
METHODS: Two beauty professionals with suspected OA and/or OR underwent inhalation challenge, including both control challenge and work-mimicking challenges using the lash extension glue, each with a 24-h follow-up. Volatile organic compounds (VOCs) present were assessed during the lash extension glue challenge. The glues were analysed for their (meth)acrylate content.
RESULTS：Both beauty professionals (case 1 and case 2) applied lash extensions regularly for several hours per day as part of their work and had work-related rhinitis. Case 1 had a longer history of lash extension work and also had asthmatic symptoms. The first lash extension glue challenge was negative in both cases, but positive OR reactions were detected in the second test. Case 1 also had a late asthmatic reaction. During the lash extension glue challenge, VOC were present in total concentrations below the irritant threshold and ethylcyanoacrylate (ECA) was detected in a concentration of 0.4mg/m3. Chemical analysis of the glues revealed ECA was the major component.
CONCLUSIONS:Application of eyelash extensions using small amounts of cyanoacrylate-based glues can cause OA and OR.

Occup Med (Lond). 2013 Apr 3. [Epub ahead of print]