LTC4S基因-444A/C多态性与哮喘风险的关系：荟萃分析
2012/10/11
摘要
背景和目的：白三烯C4合成酶（LTC4S）基因-444A/C多态性与哮喘易感相关，但大量研究并未给出最终结论。本试验采用荟萃分析，研究LTC4S基因-444A/C多态性与哮喘风险的相关性。
方法：检索Pubmed、Embase、CNKI和万方数据库。采用Revman4.2和STATA10.0进行统计学分析。
结果：13项病例对照研究的3042例病例和1902例对照进入荟萃分析。结果显示，变异体C等位基因携带者（CC+AC）与AA纯合子患者相比，其哮喘风险并未增加/下降（CC + AC vs. AA: OR = 1.13, 95% CI = 1.00-1.28，P= 0.06）。基于年龄、种族和阿司匹林敏感性的亚组分析显示，白种人（OR = 1.21, 95% CI = 1.02-1.44，P= 0.03）、阿司匹林耐受人群（OR = 1.36, 95% CI = 1.12-1.65，P= 0.002）的哮喘风险显著增加。
结论：本项荟萃分析显示，LTC4S 基因的-444A/C多态性可能是白种人和阿司匹林耐受人群的一个危险因素。有必要进行更多研究证实我们的结果。
（刘国梁 审校）
Arch Med Res. 2012 Aug 9. [Epub ahead of print]
The -444A/C Polymorphism in the LTC4S Gene and Risk of Asthma: Meta-analysis.
Zhang Y, Huang H, Cheng X, Zhang J, Xiang Z, Yang M, Tian C, Huang J, Fan H.
Source
Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Abstract
BACKGROUND AND AIMS: The -444A/C polymorphism in the leukotriene C4 synthase (LTC4S) gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study was to investigate the association between the -444A/C polymorphism in the LTC4S gene and asthma risk using meta-analysis.
METHODS: We searched Pubmed, Embase, CNKI and Wanfang databases. Statistical analysis was performed using the software Revman4.2 and STATA10.0.
RESULTS: A total of 3042 cases and 1902 controls in 13 case-control studies were included in the meta-analysis. The results indicated that the variant C allele carriers (CC + AC) did not have increased/decreased risk of asthma when compared with the homozygote AA (CC + AC vs. AA: OR = 1.13, 95% CI = 1.00-1.28, p = 0.06). In the subgroup analysis by age, ethnicity and aspirin sensitivity, significantly elevated risks were found only in Caucasians (OR = 1.21, 95% CI = 1.02-1.44, p = 0.03) and aspirin-tolerant populations (OR = 1.36, 95% CI = 1.12-1.65, p = 0.002) but not in other subgroups.
CONCLUSIONS: This meta-analysis suggested that the -444A/C polymorphism in the LTC4S gene would be a risk factor for asthma in Caucasians and aspirin-tolerant populations. Future studies are needed to validate our results.
Arch Med Res. 2012 Aug 9. [Epub ahead of print]
