无哮喘健康成人中的肥胖症、脂联素和呼出气一氧化氮
2011/05/12
摘要
背景：流行病学研究显示，肥胖与哮喘的进展、严重程度及其控制紧密相关。然而，肥胖对无哮喘个体气道炎症的影响尚不清楚。本试验旨在研究呼出气一氧化氮分数(FeNO)（嗜酸性气道炎症的标志物）是否与无哮喘的健康成人肥胖相关。
方法：在117名过去无哮喘诊断、当前无哮喘症状的成人中，检测FeNO 、血清脂肪来源激素和脂肪素水平。采用相关分析和单变量、多变量线性回归分析，研究FeNO与肥胖相关检测指标（体重指数、身体脂肪量、身体脂肪比例）间的关系。
结果：经年龄、性别、慢性鼻炎、过敏症和肺功能校正后，多变量线性回归模型显示，FeNO与体重指数、身体脂肪含量、身体脂肪比例无显著相关性。此外，FeNO与血清瘦素、脂联素、肿瘤坏死因子-α和白介素6无显著相关性。
结论：上述结果表明，无哮喘的健康成人，肥胖对嗜酸性粒细胞气道炎症无显著影响，脂肪组织来源的激素和全身炎症也对嗜酸性粒细胞气道炎症无影响。
(林江涛 审校)
J Asthma. 2011 Mar;48(2):177-82. Epub 2011 Jan 12.
Adiposity, adipokines, and exhaled nitric oxide in healthy adults without asthma.
Kim SH, Kim TH, Lee JS, Koo TY, Lee CB, Yoon HJ, Shin DH, Park SS, Sohn JW.
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Abstract
Background. Epidemiological studies have shown that obesity/adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity/adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity/adiposity in nonasthmatic healthy adults.
Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity/adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses.
Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-α, or interleukin (IL)-6 was observed.
Conclusions. These findings suggest that in healthy subjects without asthma, obesity/adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation.
J Asthma. 2011 Mar;48(2):177-82. Epub 2011 Jan 12.
背景：流行病学研究显示，肥胖与哮喘的进展、严重程度及其控制紧密相关。然而，肥胖对无哮喘个体气道炎症的影响尚不清楚。本试验旨在研究呼出气一氧化氮分数(FeNO)（嗜酸性气道炎症的标志物）是否与无哮喘的健康成人肥胖相关。
方法：在117名过去无哮喘诊断、当前无哮喘症状的成人中，检测FeNO 、血清脂肪来源激素和脂肪素水平。采用相关分析和单变量、多变量线性回归分析，研究FeNO与肥胖相关检测指标（体重指数、身体脂肪量、身体脂肪比例）间的关系。
结果：经年龄、性别、慢性鼻炎、过敏症和肺功能校正后，多变量线性回归模型显示，FeNO与体重指数、身体脂肪含量、身体脂肪比例无显著相关性。此外，FeNO与血清瘦素、脂联素、肿瘤坏死因子-α和白介素6无显著相关性。
结论：上述结果表明，无哮喘的健康成人，肥胖对嗜酸性粒细胞气道炎症无显著影响，脂肪组织来源的激素和全身炎症也对嗜酸性粒细胞气道炎症无影响。
(林江涛 审校)
J Asthma. 2011 Mar;48(2):177-82. Epub 2011 Jan 12.
Adiposity, adipokines, and exhaled nitric oxide in healthy adults without asthma.
Kim SH, Kim TH, Lee JS, Koo TY, Lee CB, Yoon HJ, Shin DH, Park SS, Sohn JW.
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Abstract
Background. Epidemiological studies have shown that obesity/adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity/adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity/adiposity in nonasthmatic healthy adults.
Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity/adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses.
Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-α, or interleukin (IL)-6 was observed.
Conclusions. These findings suggest that in healthy subjects without asthma, obesity/adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation.
J Asthma. 2011 Mar;48(2):177-82. Epub 2011 Jan 12.
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比较GINA标准、儿童哮喘控制测试和哮喘控制测试
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严重哮喘患者中肥胖与哮喘控制差的相关性
