严重哮喘患者中肥胖与哮喘控制差的相关性
2011/05/12
摘要
背景：哮喘已经成为一个公共的健康问题，常常导致患者住院治疗，甚至死亡，特别是严重哮喘。诸多研究显示，肥胖与哮喘存在相关性。
目的：本试验旨在巴西严重哮喘患者中研究哮喘控制与肥胖的关系。
方法：本项横断面研究在巴西巴伊亚州哮喘控制计划入选的门诊患者中进行。受试者包括508名严重哮喘患者，年龄大于18岁。所有参与者均完成有关社会人口统计学和临床相关的问卷调查，以收集哮喘及其共患病（如鼻炎和胃食管反流病等）的相关信息。同时，参与者完成哮喘控制问卷调查，并进行肺活量检测，测定身高、体重、腰围和臀围。
结果：Logistic回归分析显示，体重指数与未控制的哮喘存在正相关（OR：1.5; 95%CI：1.02-2.20）。慢性鼻炎和胃食管反流症状同样与未控制的哮喘相关(分别为OR：3.68, 95% CI：1.50-9.01和OR：2.78, 95% CI：1.91-4.03)。腰围与臀围比值与哮喘控制无关。
结论：严重哮喘患者与体重指数正常患者相比，肥胖患者更容易出现未控制的哮喘。然而，并不表示肥胖与哮喘控制较差之间存在因果关系。有必要进一步研究肥胖与哮喘转归间的关系。
（林江涛 审校）
J Asthma. 2011 Mar;48(2):171-6. Epub 2011 Jan 29.
Obesity and poor asthma control in patients with severe asthma.
Barros LL, Souza-Machado A, Corrêa LB, Santos JS, Cruz C, Leite M, Castro L, Coelho AC, Almeida P, Cruz AA.
Department of Medicine, Faculdade de Medicina da Bahia, Federal University of Bahia, Bahia and National Research Council (CNPq), Salvador, Bahia, Brazil.
Abstract
Background. Asthma is a public health problem as it leads to hospitalization and eventual death, particularly in its severe forms. Many studies have demonstrated an association between obesity and asthma.
Objective. The aim of this study was to investigate the relationship between obesity and asthma control in a group of patients at a reference center for severe asthma in Brazil.
Methods. This cross-sectional study was conducted in the outpatient central reference clinic of the Program for Control of Asthma in the State of Bahia. It included 508 subjects with severe asthma of both genders and above 18 years of age. All the participants answered a sociodemographic and a clinical questionnaire to collect information on their asthma and comorbidities, such as rhinitis and gastro-esophageal reflux disease (GERD). Participants also completed the Asthma Control Questionnaire, performed a spirometry test, and had their weight, height, and waist and hip circumferences registered.
Results. Logistic regression analysis demonstrated a positive association between body mass index (BMI) and uncontrolled asthma [odds ratio (OR) 1.5; 95% confidence interval (CI) 1.02-2.20]. Symptoms of chronic rhinitis and GERD were also significantly associated with uncontrolled asthma (OR 3.68, 95% CI 1.50-9.01; and OR 2.78, 95% CI 1.91-4.03, respectively). There was no correlation between waist-to-hip ratios and asthma control.
Conclusion. In our sample of patients with severe asthma, those who were obese were more likely to have uncontrolled asthma than patients with a normal BMI. Nevertheless, this is not conclusive evidence for a direct causal association between obesity and poor asthma control. Future studies are necessary to dissect the relationship between obesity and asthma outcomes.
J Asthma. 2011 Mar;48(2):171-6. Epub 2011 Jan 29.
背景：哮喘已经成为一个公共的健康问题，常常导致患者住院治疗，甚至死亡，特别是严重哮喘。诸多研究显示，肥胖与哮喘存在相关性。
目的：本试验旨在巴西严重哮喘患者中研究哮喘控制与肥胖的关系。
方法：本项横断面研究在巴西巴伊亚州哮喘控制计划入选的门诊患者中进行。受试者包括508名严重哮喘患者，年龄大于18岁。所有参与者均完成有关社会人口统计学和临床相关的问卷调查，以收集哮喘及其共患病（如鼻炎和胃食管反流病等）的相关信息。同时，参与者完成哮喘控制问卷调查，并进行肺活量检测，测定身高、体重、腰围和臀围。
结果：Logistic回归分析显示，体重指数与未控制的哮喘存在正相关（OR：1.5; 95%CI：1.02-2.20）。慢性鼻炎和胃食管反流症状同样与未控制的哮喘相关(分别为OR：3.68, 95% CI：1.50-9.01和OR：2.78, 95% CI：1.91-4.03)。腰围与臀围比值与哮喘控制无关。
结论：严重哮喘患者与体重指数正常患者相比，肥胖患者更容易出现未控制的哮喘。然而，并不表示肥胖与哮喘控制较差之间存在因果关系。有必要进一步研究肥胖与哮喘转归间的关系。
（林江涛 审校）
J Asthma. 2011 Mar;48(2):171-6. Epub 2011 Jan 29.
Obesity and poor asthma control in patients with severe asthma.
Barros LL, Souza-Machado A, Corrêa LB, Santos JS, Cruz C, Leite M, Castro L, Coelho AC, Almeida P, Cruz AA.
Department of Medicine, Faculdade de Medicina da Bahia, Federal University of Bahia, Bahia and National Research Council (CNPq), Salvador, Bahia, Brazil.
Abstract
Background. Asthma is a public health problem as it leads to hospitalization and eventual death, particularly in its severe forms. Many studies have demonstrated an association between obesity and asthma.
Objective. The aim of this study was to investigate the relationship between obesity and asthma control in a group of patients at a reference center for severe asthma in Brazil.
Methods. This cross-sectional study was conducted in the outpatient central reference clinic of the Program for Control of Asthma in the State of Bahia. It included 508 subjects with severe asthma of both genders and above 18 years of age. All the participants answered a sociodemographic and a clinical questionnaire to collect information on their asthma and comorbidities, such as rhinitis and gastro-esophageal reflux disease (GERD). Participants also completed the Asthma Control Questionnaire, performed a spirometry test, and had their weight, height, and waist and hip circumferences registered.
Results. Logistic regression analysis demonstrated a positive association between body mass index (BMI) and uncontrolled asthma [odds ratio (OR) 1.5; 95% confidence interval (CI) 1.02-2.20]. Symptoms of chronic rhinitis and GERD were also significantly associated with uncontrolled asthma (OR 3.68, 95% CI 1.50-9.01; and OR 2.78, 95% CI 1.91-4.03, respectively). There was no correlation between waist-to-hip ratios and asthma control.
Conclusion. In our sample of patients with severe asthma, those who were obese were more likely to have uncontrolled asthma than patients with a normal BMI. Nevertheless, this is not conclusive evidence for a direct causal association between obesity and poor asthma control. Future studies are necessary to dissect the relationship between obesity and asthma outcomes.
J Asthma. 2011 Mar;48(2):171-6. Epub 2011 Jan 29.
上一篇：
无哮喘健康成人中的肥胖症、脂联素和呼出气一氧化氮
下一篇：
不同严重程度的远端胃食管反流哮喘患儿，其哮喘临床表现也不同
