比较GINA标准、儿童哮喘控制测试和哮喘控制测试
2011/05/12
摘要
多个工具可用于检测儿童哮喘控制水平。本试验旨在比较GINA指南、儿童哮喘控制测试(C-ACT)和哮喘控制测试在检测儿童哮喘控制中的差异。145名哮喘儿童入选本研究，并填充以网络为基础的每日饮食卡，连续4周，主要调查哮喘症状、急救用药、活动受限，随后进行C-ACT和ACT检测。C-ACT和ACT中采用截止值为19来预测未控制哮喘。基于GINA标准，71名儿童（51%）哮喘未控制，19名(14%)儿童哮喘完全控制。与GINA指南相比，C-ACT和ACT的受试者工作曲线(ROC)的曲线下面积(AUC)分别为0.89和0.92。C-ACT和ACT采用19作为截止值时，其预测哮喘未控制的敏感性分别为33%和66%。在预测哮喘未控制上，C-ACT和ACT与GINA标准具有很好相关性，但如果采用常用的C-ACT和ACT截止值，获得的哮喘未控制儿童比例要低于GINA评价的哮喘未控制儿童比例。
（刘国梁 审校）
Eur Respir J. 2011 Mar 15. [Epub ahead of print]
Comparing GINA criteria with the Childhood Asthma Control Test and Asthma Control Test.
Koolen BB, Pijnenburg MW, Brackel HJ, Landstra AM, van den Berg NJ, Merkus PJ, Hop WC, Vaessen-Verberne AA.
Langendijk 75, 4819 EV Breda.
Abstract
Several tools are useful in detecting uncontrolled asthma in children. The aim of this study was to compare GINA guidelines with the Childhood Asthma Control Test (C-ACT) and the Asthma Control Test (ACT) in detecting uncontrolled asthma in children. 145 children with asthma filled in a web-based daily diary card for 4 weeks on symptoms, use of rescue medication and limitations of activities, followed by either the C-ACT or ACT. For predicting uncontrolled asthma, cut-off points of 19 for C-ACT and ACT were used. According to GINA guidelines, asthma was uncontrolled in 71 children (51%) and completely controlled in 19 children (14%). The area under the curve (AUC) in the Receiver Operating Characteristic (ROC) curves for C-ACT and ACT versus GINA guidelines were 0.89 and 0.92, respectively. Cut-off points of 19 for C-ACT and ACT resulted in a sensitivity of 33% and 66% in predicting uncontrolled asthma, respectively. C-ACT and ACT correlate well with GINA criteria in predicting uncontrolled asthma, but commonly used cut-off points for C-ACT and ACT seem to underestimate the proportion of children with uncontrolled asthma as defined by GINA.
Eur Respir J. 2011 Mar 15. [Epub ahead of print]
多个工具可用于检测儿童哮喘控制水平。本试验旨在比较GINA指南、儿童哮喘控制测试(C-ACT)和哮喘控制测试在检测儿童哮喘控制中的差异。145名哮喘儿童入选本研究，并填充以网络为基础的每日饮食卡，连续4周，主要调查哮喘症状、急救用药、活动受限，随后进行C-ACT和ACT检测。C-ACT和ACT中采用截止值为19来预测未控制哮喘。基于GINA标准，71名儿童（51%）哮喘未控制，19名(14%)儿童哮喘完全控制。与GINA指南相比，C-ACT和ACT的受试者工作曲线(ROC)的曲线下面积(AUC)分别为0.89和0.92。C-ACT和ACT采用19作为截止值时，其预测哮喘未控制的敏感性分别为33%和66%。在预测哮喘未控制上，C-ACT和ACT与GINA标准具有很好相关性，但如果采用常用的C-ACT和ACT截止值，获得的哮喘未控制儿童比例要低于GINA评价的哮喘未控制儿童比例。
（刘国梁 审校）
Eur Respir J. 2011 Mar 15. [Epub ahead of print]
Comparing GINA criteria with the Childhood Asthma Control Test and Asthma Control Test.
Koolen BB, Pijnenburg MW, Brackel HJ, Landstra AM, van den Berg NJ, Merkus PJ, Hop WC, Vaessen-Verberne AA.
Langendijk 75, 4819 EV Breda.
Abstract
Several tools are useful in detecting uncontrolled asthma in children. The aim of this study was to compare GINA guidelines with the Childhood Asthma Control Test (C-ACT) and the Asthma Control Test (ACT) in detecting uncontrolled asthma in children. 145 children with asthma filled in a web-based daily diary card for 4 weeks on symptoms, use of rescue medication and limitations of activities, followed by either the C-ACT or ACT. For predicting uncontrolled asthma, cut-off points of 19 for C-ACT and ACT were used. According to GINA guidelines, asthma was uncontrolled in 71 children (51%) and completely controlled in 19 children (14%). The area under the curve (AUC) in the Receiver Operating Characteristic (ROC) curves for C-ACT and ACT versus GINA guidelines were 0.89 and 0.92, respectively. Cut-off points of 19 for C-ACT and ACT resulted in a sensitivity of 33% and 66% in predicting uncontrolled asthma, respectively. C-ACT and ACT correlate well with GINA criteria in predicting uncontrolled asthma, but commonly used cut-off points for C-ACT and ACT seem to underestimate the proportion of children with uncontrolled asthma as defined by GINA.
Eur Respir J. 2011 Mar 15. [Epub ahead of print]
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