延迟戒烟是否与戒烟成功率较低相关
2011/11/22
摘要
前言：延迟戒烟可能是戒烟积极性较低的原因或标志。我们对近期的一项临床试验结果进行了二次分析，以考查上述假设的合理性。该项临床研究允许吸烟者在设定的戒烟时间内有一定的机动性。
方法：该试验利用主动要求戒烟的吸烟者比较了尼古丁含片突然戒烟和逐步戒烟的效果。突然戒烟组的吸烟者设定在研究开始后的1周至3周间戒烟，逐步戒烟组的吸烟者设定在研究开始后的3周至5周内戒烟。研究延迟戒烟是否与较低的戒烟成功率相关。
结果：对于两组设定戒烟时间的吸烟者，做出戒烟决定的可能性较小，更有可能早期复吸，而且随访6个月后，戒断的可能性较小（无显著性）。在指定时间后戒断的吸烟者更有可能复吸，而且戒断的可能性要低于指定时间前或指定时间内吸烟者（无显著性）。
结论：对于主动寻求戒烟的吸烟者，延迟戒烟能预测戒烟成功率较低。这是否是导致戒烟率低的原因尚不清楚。未来需要类似的研究证实我们的研究结果。如果延迟戒烟能降低戒断率，戒烟的治疗应该是在治疗开始后尽早鼓励吸烟者戒烟。
（陈欣 审校）
Nicotine Tob Res. 2011 Sep 8. [Epub ahead of print]
Is Delaying a Quit Attempt Associated With Less Success?
Hughes JR, Callas PW.
Source
Department of Psychiatry, University of Vermont, UHC Campus, Mailstop #482, 1 South Prospect Street, Burlington, VT 05401, USA. john.hughes@uvm.edu.
Abstract
INTRODUCTION:Delaying a quit date until later may be a cause of, or marker for, low motivation to quit. We tested this possibility in a secondary analysis of a recent clinical trial that allowed smokers flexibility in setting a quit date.
METHODS:The trial compared quitting abruptly versus gradually with nicotine lozenge among smokers who were actively trying to quit. Smokers in the abrupt conditions set a quit date sometime between 1 and 3 weeks after study onset; smokers in the gradual condition set a quit date sometime between 3 and 5 weeks after study entry. Within each condition, we examined whether later quit dates were associated with less success.
RESULTS:Independent of study condition, those who set a later quit date were less likely to make a quit attempt, more likely to lapse early on, and showed a nonsignificant trend to be less likely to be abstinent at 6-month follow-up. Those who quit after their planned quit date were more likely to lapse and showed a nonsignificant trend toward less abstinence than those who quit before or on their quit date.
CONCLUSIONS: Delaying a quit attempt prospectively predicts less success among smokers actively trying to quit. Whether this represents a causal effect is unclear. Further replication tests of our findings and, possibly, randomized trials of quitting sooner versus later are indicated. If delaying reduces cessation success, then treatments for smoking cessation should encourage quitting very soon upon treatment entry.
Nicotine Tob Res. 2011 Sep 8. [Epub ahead of print]
前言：延迟戒烟可能是戒烟积极性较低的原因或标志。我们对近期的一项临床试验结果进行了二次分析，以考查上述假设的合理性。该项临床研究允许吸烟者在设定的戒烟时间内有一定的机动性。
方法：该试验利用主动要求戒烟的吸烟者比较了尼古丁含片突然戒烟和逐步戒烟的效果。突然戒烟组的吸烟者设定在研究开始后的1周至3周间戒烟，逐步戒烟组的吸烟者设定在研究开始后的3周至5周内戒烟。研究延迟戒烟是否与较低的戒烟成功率相关。
结果：对于两组设定戒烟时间的吸烟者，做出戒烟决定的可能性较小，更有可能早期复吸，而且随访6个月后，戒断的可能性较小（无显著性）。在指定时间后戒断的吸烟者更有可能复吸，而且戒断的可能性要低于指定时间前或指定时间内吸烟者（无显著性）。
结论：对于主动寻求戒烟的吸烟者，延迟戒烟能预测戒烟成功率较低。这是否是导致戒烟率低的原因尚不清楚。未来需要类似的研究证实我们的研究结果。如果延迟戒烟能降低戒断率，戒烟的治疗应该是在治疗开始后尽早鼓励吸烟者戒烟。
（陈欣 审校）
Nicotine Tob Res. 2011 Sep 8. [Epub ahead of print]
Is Delaying a Quit Attempt Associated With Less Success?
Hughes JR, Callas PW.
Source
Department of Psychiatry, University of Vermont, UHC Campus, Mailstop #482, 1 South Prospect Street, Burlington, VT 05401, USA. john.hughes@uvm.edu.
Abstract
INTRODUCTION:Delaying a quit date until later may be a cause of, or marker for, low motivation to quit. We tested this possibility in a secondary analysis of a recent clinical trial that allowed smokers flexibility in setting a quit date.
METHODS:The trial compared quitting abruptly versus gradually with nicotine lozenge among smokers who were actively trying to quit. Smokers in the abrupt conditions set a quit date sometime between 1 and 3 weeks after study onset; smokers in the gradual condition set a quit date sometime between 3 and 5 weeks after study entry. Within each condition, we examined whether later quit dates were associated with less success.
RESULTS:Independent of study condition, those who set a later quit date were less likely to make a quit attempt, more likely to lapse early on, and showed a nonsignificant trend to be less likely to be abstinent at 6-month follow-up. Those who quit after their planned quit date were more likely to lapse and showed a nonsignificant trend toward less abstinence than those who quit before or on their quit date.
CONCLUSIONS: Delaying a quit attempt prospectively predicts less success among smokers actively trying to quit. Whether this represents a causal effect is unclear. Further replication tests of our findings and, possibly, randomized trials of quitting sooner versus later are indicated. If delaying reduces cessation success, then treatments for smoking cessation should encourage quitting very soon upon treatment entry.
Nicotine Tob Res. 2011 Sep 8. [Epub ahead of print]
上一篇：
住院患者康复治疗期间和治疗后网络戒烟干预的效果——半随机对照试验
下一篇：
戒烟的自我效能是吸烟行为变化的原因还是表现
