产前氧化平衡与青春期哮喘和过敏性疾病的风险
2019/09/09
摘要
背景：胎儿氧化平衡（当保护性产前因素抵消氧化应激源时实现）可能对预防哮喘和过敏性疾病至关重要。我们在青少年哮喘和过敏性疾病的模型中检查了产前摄入的假设保护性营养素（包括抗氧化剂）以及潜在的氧化应激源。
方法：我们使用了Viva项目中996个母子对的数据。感兴趣的是母体孕前体重指数和产前营养素（维生素D、C和E，β-胡萝卜素，叶酸，胆碱和n-3及n-6多不饱和脂肪酸（PUFAs）的能量调整摄入量）），空气污染物暴露（居住特定的孕晚期黑碳或PM2.5），对乙酰氨基酚和吸烟。 结果是后代中位年龄为12.9岁时的哮喘，过敏性鼻炎和过敏原致敏。对数据进行逻辑回归。对连续暴露进行对数变换并将其建模为z分数。
结果：结果显示维生素D（OR = 0.69，过敏性鼻炎的95％CI 0.53-0.89），n-3 PUFA EPA（二十碳五烯酸）和DHA（二十二碳六烯酸）的总和（OR = 0.81，哮喘的95％CI 0.66-0.99）和n-3PUFAα亚麻酸（OR = 0.78，过敏原致敏的95％CI 0.64-0.95）起到保护性作用。 黑碳和PM2.5与过敏原致敏风险升高约30％相关。保护性营养摄入和氧化应激源没有观察到乘法相互作用。
结论：我们确定了潜在的保护性产前营养素（维生素D，n-3 PUFAs）以及可能改变进入青春期时的哮喘和过敏性疾病的不良产前促氧化剂暴露。
Prenatal Oxidative Balance and Risk of Asthma and Allergic Disease in Adolescence.
Sordillo JE, Rifas-Shiman SL, Switkowski K, Coull B, Gibson H, Rice M, Platts-Mills T, Kloog I, Litonjua AA, Gold DR, Oken E.
Abstract
RESULTS:We observed protective associations for Vitamin D (OR = 0.69; 95% CI 0.53 to 0.89 for allergic rhinitis), the sum of n-3 PUFAs EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) (OR=0.81, 95% CI 0.66 to 0.99 for current asthma)), and n-3 PUFA alpha linolenic acid (OR=0.78; 95% CI 0.64 to 0.95 for allergen sensitization). Black carbon and PM2.5 were associated with ∼30% elevated risk for allergen sensitization. No multiplicative interactions were observed for protective nutrient intakes with sources of oxidative stress.
CONCLUSIONS:We identified potential protective prenatal nutrients (Vitamin D, n-3 PUFAs), as well as adverse prenatal pro-oxidant exposures that may alter risk of asthma and allergic disease into adolescence.
背景：胎儿氧化平衡（当保护性产前因素抵消氧化应激源时实现）可能对预防哮喘和过敏性疾病至关重要。我们在青少年哮喘和过敏性疾病的模型中检查了产前摄入的假设保护性营养素（包括抗氧化剂）以及潜在的氧化应激源。
方法：我们使用了Viva项目中996个母子对的数据。感兴趣的是母体孕前体重指数和产前营养素（维生素D、C和E，β-胡萝卜素，叶酸，胆碱和n-3及n-6多不饱和脂肪酸（PUFAs）的能量调整摄入量）），空气污染物暴露（居住特定的孕晚期黑碳或PM2.5），对乙酰氨基酚和吸烟。 结果是后代中位年龄为12.9岁时的哮喘，过敏性鼻炎和过敏原致敏。对数据进行逻辑回归。对连续暴露进行对数变换并将其建模为z分数。
结果：结果显示维生素D（OR = 0.69，过敏性鼻炎的95％CI 0.53-0.89），n-3 PUFA EPA（二十碳五烯酸）和DHA（二十二碳六烯酸）的总和（OR = 0.81，哮喘的95％CI 0.66-0.99）和n-3PUFAα亚麻酸（OR = 0.78，过敏原致敏的95％CI 0.64-0.95）起到保护性作用。 黑碳和PM2.5与过敏原致敏风险升高约30％相关。保护性营养摄入和氧化应激源没有观察到乘法相互作用。
结论：我们确定了潜在的保护性产前营养素（维生素D，n-3 PUFAs）以及可能改变进入青春期时的哮喘和过敏性疾病的不良产前促氧化剂暴露。
(中日友好医院呼吸与危重症医学科 王瑞茵 摘译 林江涛 审校)
(J Allergy Clin Immunol. 2019 Aug 19. pii: S0091-6749(19)31048-6. doi: 10.1016/j.jaci.2019.07.044. [Epub ahead of print])
(J Allergy Clin Immunol. 2019 Aug 19. pii: S0091-6749(19)31048-6. doi: 10.1016/j.jaci.2019.07.044. [Epub ahead of print])
Prenatal Oxidative Balance and Risk of Asthma and Allergic Disease in Adolescence.
Sordillo JE, Rifas-Shiman SL, Switkowski K, Coull B, Gibson H, Rice M, Platts-Mills T, Kloog I, Litonjua AA, Gold DR, Oken E.
Abstract
background:Fetal oxidative balance (achieved when protective prenatal factors counteract sources of oxidative stress), may be critical for preventing asthma and allergic disease. We examined prenatal intakes of hypothesized protective nutrients (including antioxidants) in conjunction with potential sources of oxidative stress, in models for adolescent asthma and allergic disease.
MEthodS:We used data from 996 mother-child pairs in Project Viva. Exposures of interest were maternal pre-pregnancy body mass index and prenatal nutrients (energy-adjusted intakes of vitamins D, C, and E, β-carotene, folate, choline, and n-3 and n-6 polyunsaturated fatty acids (PUFAs)), air pollutant exposures (residence-specific 3rd trimester black carbon or PM2.5), acetaminophen, and smoking. Outcomes were offspring current asthma, allergic rhinitis, and allergen sensitization at a median age of 12.9 years. We performed logistic regression. Continuous exposures were log-transformed and modeled as z-scores.RESULTS:We observed protective associations for Vitamin D (OR = 0.69; 95% CI 0.53 to 0.89 for allergic rhinitis), the sum of n-3 PUFAs EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) (OR=0.81, 95% CI 0.66 to 0.99 for current asthma)), and n-3 PUFA alpha linolenic acid (OR=0.78; 95% CI 0.64 to 0.95 for allergen sensitization). Black carbon and PM2.5 were associated with ∼30% elevated risk for allergen sensitization. No multiplicative interactions were observed for protective nutrient intakes with sources of oxidative stress.
CONCLUSIONS:We identified potential protective prenatal nutrients (Vitamin D, n-3 PUFAs), as well as adverse prenatal pro-oxidant exposures that may alter risk of asthma and allergic disease into adolescence.
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多种户外环境因素对哮喘急性发作风险的短期影响：年龄分层时间序列分析
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室内细菌微生物群与10.5岁前哮喘的发展
