多种户外环境因素对哮喘急性发作风险的短期影响：年龄分层时间序列分析
2019/10/17
背景：尽管不同年龄组的哮喘急性发作（AEs）对环境因素的敏感性不同，但尚无全面研究检查环境因素对AEs的年龄分层影响。本文旨在研究在年龄分层组（婴儿，学龄前儿童，学龄儿童，成人和老人）上户外环境因素（空气污染物，天气状况，空气过敏原和呼吸道病毒性流行病）对哮喘急性发作的短期影响。
方法：我们对2008年至2012年在韩国首尔市的四组室外环境因素对AE的短期影响进行了年龄分层分析。统计分析采用泊松广义线性回归模型，且分布滞后非线性模型用于识别滞后和非线性效应，以及收敛交叉映射用于识别因果关系。
结果：对总人口的分析（n = 10,233,519）表明，在研究期间有28,824例AE事件需要急诊就诊。 昼夜温度范围对儿童（婴儿，学龄前儿童和学龄儿童）和老年人有显著影响（RR：分别为1.056-1.078和1.016）。树木和杂草花粉，人鼻病毒和流感病毒对学龄儿童具有显著影响（RR：分别为1.014、1.040、1.042和1.038）。树花粉和流感病毒对成年人具有显著影响（RR：分别为1.026和1.044）。室外空气污染物（PM10，NO2，O3，CO和SO2）在所有年龄段（婴儿中的CO和SO2除外）均具有明显的短期影响。
结论：这些发现提供了开发量身定制的策略以防止不同年龄组的哮喘急性发作事件。
(J Allergy Clin Immunol. 2019 Sep 16. pii: S0091-6749(19)31185-6. doi: 10.1016/j.jaci.2019.08.037. [Epub ahead of print])
Short-term effects of multiple outdoor environmental factors on risk of asthma exacerbations: age-stratified time-series analysis.
Lee SW, Yon DK, James CC, Lee S, Koh HY, Sheen YH, Oh JW, Han MY, Sugihara G.
Abstract
background:Although the different age groups had differences in sensitivity of asthma exacerbations (AEs) to the environmental factors, no comprehensive study has examined the age-stratified effects of environmental factors on AEs. To examine the short-term effects of age-stratified groups (infants, preschool children, school-aged children, adults, and elderly) of outdoor environmental factors (air pollutants, weather conditions, aeroallergens, and respiratory viral epidemics) on asthma exacerbations.
MEthodS:We performed an age-stratified analysis of the short-term effects of four groups of outdoor environmental factors on AEs in Seoul Metropolitan City (Korea) from 2008 and 2012. The statistical analysis employed a Poisson generalized linear regression model, with a distributed lag non-linear model for identification of lagged and non-linear effects and convergent cross mapping for identification of causal associations.RESULTS:Analysis of the total population (n=10,233,519) indicated there were 28,824 AE events requiring admission to an emergency department during the study period. Diurnal temperature range had significant effects in pediatric (infants, preschool children, and school-aged children) and elderly people (RR: 1.056-1.078 and 1.016, respectively). Tree and weed pollen, human rhinovirus, and influenza virus had significant effects in school-age children (RR: 1.014, 1.040, 1.042, and 1.038, respectively). Tree pollen and influenza virus had significant effects in adults (RR: 1.026 and 1.044, respectively). Outdoor air pollutants (PM10, NO2, O3, CO, and SO2) had significant short-term effects in all age groups (except for CO and SO2 in infants).
CONCLUSIONS:These findings provide the need for the development of tailored strategies to prevent asthma exacerbation events in different age groups.
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多种户外环境因素对哮喘发作风险的短期影响:年龄分层时间序列分析
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产前氧化平衡与青春期哮喘和过敏性疾病的风险
