哮喘和前列腺癌患病风险的相关性研究
2018/11/14
摘要
目的：哮喘和患前列腺癌的风险之间的关系仍然不明确。我们研究的目的是评估哮喘与前列腺癌发病的关系。
方法：我们在PubMed、Embase和Cochrane数据库中搜索了评估哮喘与前列腺癌风险关系的文章，直到2015年10月。提取优势比(OR)，计算相应的95%置信区间(CI)。我们使用随机效应模型来计算哮喘和前列腺癌风险之间的联合关系。
结果：14项研究涉及哮喘和前列腺癌患病风险之间的关系评估。哮喘与总体人群(OR值0.994,95% CI 0.836-1.182)、白种人(OR值0.922,95% CI 0.825-1.030)和亚洲人(OR值 5.022,95% CI 0.415-60.793)的前列腺癌患病风险无关。累积分析也表明哮喘和前列腺癌患病风险之间缺乏联系。排除任何单一研究并没有显著改变结果。没有明显的发表偏倚的证据。
结论：我们的调查表明，哮喘与总体人群、白种人和亚洲人的前列腺癌患病风险无关。
Asthma and the risk of prostate cancer.
Li W1, Mao S2, Tu M3, Ge X4, Li K4, Xie F4, Song Y4, Miao Y3.
Abstract
OBJECTIVE: The association between asthma and the risk of prostate cancer remains elusive. We aimed to evaluate the relationship between asthma and the onset of prostate cancer.
METHODS: We searched PubMed, Embase, and Cochrane databases for articles that assessed the association of asthma with the risk of prostate cancer through October 2015. We extracted odds ratio (OR) and calculated the corresponding 95% confidence interval (CI). We used random-effects models to calculate a pooled association between asthma and the risk of prostate cancer.
RESULTS: Fourteen studies were involved in the assessment of the association between asthma and prostate cancer risk. Asthma was not associated with the risk of prostate cancer in overall populations (OR 0.994, 95% CI 0.836-1.182), Caucasians (OR 0.922, 95% CI 0.825-1.030), and Asians (OR 5.022, 95% CI 0.415-60.793). The cumulative analysis also suggested a lack association between asthma and the risk of prostate cancer. Exclusion of any single study did not change the results significantly. No evidence of marked publication bias was observed.
CONCLUSIONS: Our investigation indicated that asthma was not associated with prostate cancer risk in overall populations, Caucasians, and Asians.
目的：哮喘和患前列腺癌的风险之间的关系仍然不明确。我们研究的目的是评估哮喘与前列腺癌发病的关系。
方法：我们在PubMed、Embase和Cochrane数据库中搜索了评估哮喘与前列腺癌风险关系的文章，直到2015年10月。提取优势比(OR)，计算相应的95%置信区间(CI)。我们使用随机效应模型来计算哮喘和前列腺癌风险之间的联合关系。
结果：14项研究涉及哮喘和前列腺癌患病风险之间的关系评估。哮喘与总体人群(OR值0.994,95% CI 0.836-1.182)、白种人(OR值0.922,95% CI 0.825-1.030)和亚洲人(OR值 5.022,95% CI 0.415-60.793)的前列腺癌患病风险无关。累积分析也表明哮喘和前列腺癌患病风险之间缺乏联系。排除任何单一研究并没有显著改变结果。没有明显的发表偏倚的证据。
结论：我们的调查表明，哮喘与总体人群、白种人和亚洲人的前列腺癌患病风险无关。
(中日友好医院呼吸与危重症医学科 禹汶伯 摘译 林江涛 审校)
(J Cancer Res Ther. 2018 Sep;14(Supplement): S571-S575.)
(J Cancer Res Ther. 2018 Sep;14(Supplement): S571-S575.)
Asthma and the risk of prostate cancer.
Li W1, Mao S2, Tu M3, Ge X4, Li K4, Xie F4, Song Y4, Miao Y3.
Abstract
OBJECTIVE: The association between asthma and the risk of prostate cancer remains elusive. We aimed to evaluate the relationship between asthma and the onset of prostate cancer.
METHODS: We searched PubMed, Embase, and Cochrane databases for articles that assessed the association of asthma with the risk of prostate cancer through October 2015. We extracted odds ratio (OR) and calculated the corresponding 95% confidence interval (CI). We used random-effects models to calculate a pooled association between asthma and the risk of prostate cancer.
RESULTS: Fourteen studies were involved in the assessment of the association between asthma and prostate cancer risk. Asthma was not associated with the risk of prostate cancer in overall populations (OR 0.994, 95% CI 0.836-1.182), Caucasians (OR 0.922, 95% CI 0.825-1.030), and Asians (OR 5.022, 95% CI 0.415-60.793). The cumulative analysis also suggested a lack association between asthma and the risk of prostate cancer. Exclusion of any single study did not change the results significantly. No evidence of marked publication bias was observed.
CONCLUSIONS: Our investigation indicated that asthma was not associated with prostate cancer risk in overall populations, Caucasians, and Asians.
