波兰人使用扑热息痛与患哮喘、鼻炎和湿疹的风险之间的关系的研究
2018/11/14
摘要
介绍：越来越多的流行病学研究表明，常用于儿童的扑热息痛可能是哮喘、变应性鼻炎和特应性湿疹的患病危险因素。
目的：本研究的目的是明确和描述波兰人使用扑热息痛与哮喘、变应性鼻炎和特应性湿疹症状的相关性。
方法：这项研究是ECAP项目的一部分，涉及到ISAAC和ECRHS问卷的使用。对18,617名受试者的完整问卷进行分析，其中包括10,011名(53.8%)女性。6-7岁的儿童(n=4,510)、13-14岁的青少年(n=4,721)和20-44岁的成年人(n=9,386)分别占被访者的24.2%、25.4%和50.4%。研究对象居住在8个主要城市中心和1个农村地区。分析了过去12个月扑热息痛的使用频率、哮喘、变应性鼻炎和特应性湿疹的症状。
结果：在所有评估的年龄组中，扑热息痛的使用与哮喘症状的风险有显著的剂量相关性。这是通过比较过去12月内对使用扑热息痛和没有使用扑热息痛的患者哮喘症状的优势比(OR)来证明的，这些症状包括6-7岁时胸部出现的喘息或哮鸣音，以及13-14岁和成年人因运动导致的呼吸短促，以上症状取决于过去12个月内扑热息痛的使用频率。
结论：在过去的12个月里使用扑热息痛与鼻炎和皮肤过敏症状的显著剂量依赖性增加有关，优势比证明了这一点。因此，频繁使用扑热息痛可能是波兰人群哮喘、鼻炎和皮肤过敏症状的危险因素。
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population.
Lipiec A1, Wawrzyniak ZM2, Sybilski AJ3, Samolińska-Zawisza U4, Krzych-Fałta E5, Piekarska B6, Dulny G7, Stankiewicz-Choroszucha B8, Raciborski F9, Samoliński B10.
Abstract
INTRODUCTION: A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children, may be a risk factor for asthma, allergic rhinitis, and atopic eczema.
OBJECTIVE: The aim of this study was to determine and characterize the correlation between paracetamol use and asthma, allergic rhinitis, and atopic eczema symptoms in the Polish population.
MATERIAL AND METHODS: The study is part of the ECAP project involving the use of the ISAAC and ECRHS questionnaires. Completed questionnaires of 18,617 subjects, including 10,011 (53.8%) females, were analyzed. Children aged 6-7 (n=4,510), adolescents aged 13-14 (n=4,721), and adults aged 20-44 (n=9,386) constituted 24.2%, 25.4%, and 50.4% of respondents, respectively. Study subjects lived in 8 major urban centres and one rural area. The frequency of paracetamol use during the previous 12 months and symptoms of asthma, allergic rhinitis, and atopic eczema during that period were analyzed.
RESULTS: The use of paracetamol was associated with a significant dose-dependent increase in the risk of asthma symptoms in all evaluated age groups. This was demonstrated via odds ratios (OR) for developing asthma symptoms, including wheezing or whistling in the chest in 6-7-year-olds and exercise-induced shortness of breath in 13-14-year-olds and adults, depending on the frequency of paracetamol use in the previous 12 months, compared to no paracetamol intake during that period.
CONCLUSIONS: The use of paracetamol in the last 12 months was associated with a significant dose-dependent increase in the risk of rhinitis and skin allergy symptoms, as demonstrated by the odds ratio. Therefore, frequent paracetamol use may be a risk factor for symptoms of asthma, rhinitis, and skin allergy in the Polish population.
介绍：越来越多的流行病学研究表明，常用于儿童的扑热息痛可能是哮喘、变应性鼻炎和特应性湿疹的患病危险因素。
目的：本研究的目的是明确和描述波兰人使用扑热息痛与哮喘、变应性鼻炎和特应性湿疹症状的相关性。
方法：这项研究是ECAP项目的一部分，涉及到ISAAC和ECRHS问卷的使用。对18,617名受试者的完整问卷进行分析，其中包括10,011名(53.8%)女性。6-7岁的儿童(n=4,510)、13-14岁的青少年(n=4,721)和20-44岁的成年人(n=9,386)分别占被访者的24.2%、25.4%和50.4%。研究对象居住在8个主要城市中心和1个农村地区。分析了过去12个月扑热息痛的使用频率、哮喘、变应性鼻炎和特应性湿疹的症状。
结果：在所有评估的年龄组中，扑热息痛的使用与哮喘症状的风险有显著的剂量相关性。这是通过比较过去12月内对使用扑热息痛和没有使用扑热息痛的患者哮喘症状的优势比(OR)来证明的，这些症状包括6-7岁时胸部出现的喘息或哮鸣音，以及13-14岁和成年人因运动导致的呼吸短促，以上症状取决于过去12个月内扑热息痛的使用频率。
结论：在过去的12个月里使用扑热息痛与鼻炎和皮肤过敏症状的显著剂量依赖性增加有关，优势比证明了这一点。因此，频繁使用扑热息痛可能是波兰人群哮喘、鼻炎和皮肤过敏症状的危险因素。
(中日友好医院呼吸与危重症医学科 禹汶伯 摘译 林江涛 审校)
(Ann Agric Environ Med. 2018 Sep 25;25(3):428-432.)
(Ann Agric Environ Med. 2018 Sep 25;25(3):428-432.)
The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population.
Lipiec A1, Wawrzyniak ZM2, Sybilski AJ3, Samolińska-Zawisza U4, Krzych-Fałta E5, Piekarska B6, Dulny G7, Stankiewicz-Choroszucha B8, Raciborski F9, Samoliński B10.
Abstract
INTRODUCTION: A growing number of epidemiological studies suggest that paracetamol, which is commonly used in children, may be a risk factor for asthma, allergic rhinitis, and atopic eczema.
OBJECTIVE: The aim of this study was to determine and characterize the correlation between paracetamol use and asthma, allergic rhinitis, and atopic eczema symptoms in the Polish population.
MATERIAL AND METHODS: The study is part of the ECAP project involving the use of the ISAAC and ECRHS questionnaires. Completed questionnaires of 18,617 subjects, including 10,011 (53.8%) females, were analyzed. Children aged 6-7 (n=4,510), adolescents aged 13-14 (n=4,721), and adults aged 20-44 (n=9,386) constituted 24.2%, 25.4%, and 50.4% of respondents, respectively. Study subjects lived in 8 major urban centres and one rural area. The frequency of paracetamol use during the previous 12 months and symptoms of asthma, allergic rhinitis, and atopic eczema during that period were analyzed.
RESULTS: The use of paracetamol was associated with a significant dose-dependent increase in the risk of asthma symptoms in all evaluated age groups. This was demonstrated via odds ratios (OR) for developing asthma symptoms, including wheezing or whistling in the chest in 6-7-year-olds and exercise-induced shortness of breath in 13-14-year-olds and adults, depending on the frequency of paracetamol use in the previous 12 months, compared to no paracetamol intake during that period.
CONCLUSIONS: The use of paracetamol in the last 12 months was associated with a significant dose-dependent increase in the risk of rhinitis and skin allergy symptoms, as demonstrated by the odds ratio. Therefore, frequent paracetamol use may be a risk factor for symptoms of asthma, rhinitis, and skin allergy in the Polish population.
