富含大豆油或鱼油的食物对过敏性气道炎症的保护作用
2016/07/27
摘要
背景：在西方社会，哮喘和过敏性疾病患病率增加与富含n-6脂肪酸但缺乏n-3脂肪酸的食物摄入量增加有关。本研究旨在分析用富含大豆油（富含n-6脂肪酸）或者鱼油（富含n-3脂肪酸）的食物来治疗过敏性气道炎症模型的预防效果，测量指标包括：肺炎评分、白细胞迁移、辅助性T细胞（Th）- 2（白细胞介素[IL]- 4、IL-5） 和Th1（干扰素[IFN] -γ，肿瘤坏死因子-α）细胞因子、脂氧素A4、一氧化氮、缓激肽和支气管肺泡灌洗液（BAL）或肺中的皮质酮水平。
方法：饲喂富含豆油或鱼油的食物的或标准大鼠饲料喂养的雄性Wistar大鼠用卵清蛋白白矾致敏两次，再用卵清蛋白气溶胶刺激两次。24小时后检查支气管肺泡灌洗液（BAL）和肺。
结果：富含n-6或n-3脂肪酸的两种饮食，均减弱了肺过敏性炎症反应、降低了白细胞迁移、嗜酸性粒细胞和中性粒细胞百分比、支气管肺泡灌洗液和/或肺中IL-4、IL-5、缓激肽水平，同时增加支气管肺泡灌洗液中一氧化氮的水平。此外，富含大豆油的饮食增加肺内脂氧素A4和皮质酮水平。
结论：数据表明，富含n-6脂肪酸的饮食对过敏性气道炎症有保护作用，尽管通过不同的机制，但和富含n-3脂肪酸的饮食一样具有抗炎作用，这表明这两类饮食均可作为辅助治疗或预防性治疗过敏性气道炎症。
（苏欣 审校）
J Inflamm Res. 2016 May 19;9:79-89. doi: 10.2147/JIR.S102221. eCollection 2016.
Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation.
Navarro-Xavier RA1, de Barros KV1, de Andrade IS1, Palomino Z2, Casarini DE2, Flor Silveira VL3.
Author information
Abstract
BACKGROUND:The increased prevalence of asthma and allergic diseases in westernized societies has been associated with increased intake of diets rich in n-6 fatty acids (FAs) and poor in n-3 FAs. This study aimed to analyze the prophylactic effects of treatment with a soybean oil-rich diet (rich in n-6) or fish oil (rich in n-3) in an allergic airway inflammation model on lung inflammation score, leukocyte migration, T-helper cell (Th)-2 (interleukin [IL]-4, IL-5) and Th1 (interferon [IFN]-γ, tumor necrosis factor-α) cytokines, lipoxin A4, nitric oxide, bradykinin, and corticosterone levels in bronchoalveolar lavage (BAL) or lungs.
METHODS:Male Wistar rats fed with soybean oil- or fish oil-rich diet or standard rat chow were sensitized twice with ovalbumin-alumen and challenged twice with ovalbumin aerosol. The BAL and lungs were examined 24 hours later.
RESULTS:Both diets, rich in n-6 or n-3 FAs, impaired the allergic lung inflammation and reduced leukocyte migration, eosinophil and neutrophil percentages, and IL-4/IL-5/bradykinin levels in BAL and/or lungs, as well as increased the nitric oxide levels in BAL. The soybean oil-rich diet additionally increased the levels of lipoxin A4 and corticosterone in the lungs.
CONCLUSION:Data presented demonstrated that the n-6 FA-rich diet had protective effect upon allergic airway inflammation and was as anti-inflammatory as the n-3 FA-rich diet, although through different mechanisms, suggesting that both diets could be considered as complementary therapy or a prophylactic alternative for allergic airway inflammation.
KEYWORDS:asthma; bradykinin; cytokines; lipoxin A4; n-3 fatty acids; n-6 fatty acids; nitric oxide
J Inflamm Res. 2016 May 19;9:79-89. doi: 10.2147/JIR.S102221. eCollection 2016.
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