儿童过敏性哮喘中选择型的CC和CXC趋化因子

2016/07/27

   摘要
   简介:关于在哮喘患儿中CC和CXC趋化因子的调节目前数据很少。
   目的:我们比较了过敏性哮喘患儿和健康儿童中选择型CC和CXC趋化因子的血清型。
   材料和方法:44例过敏性哮喘患者和17例健康受试者的CC趋化因子RANTES、MCP-1和CXC趋化因子IP-10、MIG、IL-8、RANTES的血清浓度采用流式微球技术进行检测。
   结果:与对照相比,所有患有哮喘的儿童的RANTES浓度明显增高,MIG水平较低。在稳定期哮喘患儿中,我们也观察到RANTES增加和MIG下降。IP-10浓度在整个哮喘组和健康对照组中相似,但与稳定期哮喘相比,急性哮喘时IP-10浓度显着增加。MCP-1和IL-8的血清浓度在所有组中相似。MIG浓度与IP-10、IL-8和CRP水平呈正相关,与嗜酸性粒细胞计数呈负相关。IP-10和嗜酸性粒细胞计数,以及FEV1和IP-10之间均呈负相关。
   结论:哮喘患儿中RANTES血清水平增加可能导致Th2型淋巴细胞进入气道增强。稳定期哮喘患儿中Th1趋化因子MIG表达的降低可能会减少对Th2细胞因子产生的对抗作用,从而强化Th2优势效应。儿童哮喘发作期间IP-10水平增加表明趋化因子是疾病加重的血清学标志物。
 
 
(苏欣 审校)
Postepy Dermatol Alergol. 2016 Apr;33(2):96-101. doi: 10.5114/ada.2016.59150. Epub 2016 May 16.

 
 
 
Selected CC and CXC chemokines in children with atopic asthma.
 
 
Machura E1, Szczepanska M1, Mazur B2, Chrobak E1, Ziora K1, Ziora D3, Kasperska-Zajac A4.
Author information

 
Abstract
INTRODUCTION:There are only limited data on CC and CXC chemokines regulation in children with asthma.
AIM:We compared the serum profile of selected CC and CXC chemokines in patients with atopic asthma and healthy children.
MATERIAL AND METHODS:Serum concentration of CC chemokines RANTES, MCP-1, and CXC chemokines IP-10, MIG, IL-8, RANTES was measured using cytometric bead array in 44 children with atopic asthma and 17 healthy subjects.
RESULTS:The concentration of RANTES was significantly higher and the MIG level was lower in all children with asthma as compared to their control counterparts. We observed increased RANTES and decreased MIG levels also in patients with stable asthma when compared with children in the control group. The IP-10 concentration was similar between the whole asthma group and healthy controls, while significantly increased levels of this chemokine in acute asthma have been observed when compared to stable asthma. For MCP-1 and IL-8, the serum concentration was similar in all compared groups. The MIG concentration correlated positively with IP-10, IL-8, and CRP levels and negatively with the eosinophil count. A negative correlation between the IP-10 and eosinophil count and a negative correlation between FEV1 and IP-10 were found.
CONCLUSIONS:An increased serum RANTES level in children with asthma may result in enhancement of Th2 lymphocyte recruitment into the airway. A decreased expression of Th1 chemokine MIG in children with stable asthma may contribute to a diminished antagonizing effect on Th2 cytokine production and hence intensify Th2 predominance. An increased IP-10 level in children during an asthma attack suggest that this chemokine is a serological marker of disease exacerbation.
KEYWORDS:IL-8; IP-10; MIG; RANTES; atopic asthma; chemokines; children
 
 
Postepy Dermatol Alergol. 2016 Apr;33(2):96-101. doi: 10.5114/ada.2016.59150. Epub 2016 May 16.
 


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