呼吸道过敏的孩子对抗空气播散的真菌的IgE抗体血清浓度
2016/06/20
摘要
背景:对有呼吸道过敏性疾病的未成年受试者总的和特异性免疫球蛋白E（IgE）抗体浓度进行评价。
方法:这是一项在10到14岁之间的未成年人中进行的一个横向类型的研究, 受试少年患有哮喘和/或过敏性鼻炎。对巴西马拉尼昂州圣路易斯市的空气播散的真菌，进行总的和特异性的IgE的定量。五个不同的地区——东西南北中——每月进行真菌取样，持续一年。共检出了20个属的真菌。通过ELISA测试选定曲霉、青霉、镰刀霉和链孢菌作为致敏抗原。用同样的方法评估总的IgE 浓度。
结果：IgE总血清浓度在97%的过敏受试者中增加了：75%受试者表现出抗曲霉的IgE浓度增加，分别有87 %、45 %、46 %的受试者表现出抗青霉、抗镰刀霉、抗链孢霉IgE抗浓度增加。
结论：过敏性的受试者对所测试的真菌同时表现出总IgE和特异性IgE的水平升高，可能是由于全年所有地方的真菌引起的多致敏性导致的。然而，确定现在研究结果的临床意义仍然是不可能的，因为大多数的数据是孤立的变量。
（苏欣 审校）
Allergy Asthma ClinImmunol. 2016 Apr 27;12:18.doi:10.1186/s13223-016-0128-y. eCollection 2016.
IgE serum concentration against airborne fungi in children with respiratory allergies.
de Barros Bezerra GF1, Haidar DM2, da Silva MA1, Filho WE1, Dos Santos RM1, Rosa IG1, de Castro Viana GM1, Zaror L3, Soares Brandão Nascimento Mdo D1.
Author information
Abstract
BACKGROUND:To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases.
METHODS:This study was a transversal-type study in 100 underage subjects between 4 and 14 years old, with asthma and/or allergic rhinitis. Total and specific IgE were quantified for airborne fungi in the city of São Luís, Maranhão, Brazil. Five distinct regions-North, South, Center, East and West-were selected so fungi could be collected monthly for 1 year. Twenty genera were identified. Aspergillus, Penicillium, Fusarium and Neurospora were selected for the preparation of sensitizing antigens from ELISA dishes. IgE total concentrations were estimated using the same method.
RESULTS: IgE total serum concentration was increased in 97 % of the atopic subjects: 75 % of the subjects presented increased IgE anti-Aspergillus concentrations, 87 % presented IgE anti-Penicillium, 45 % presented IgE anti-Fusarium, and 46 % presented IgE anti-Neurospora.
CONCLUSIONS: Atopic subjects presented simultaneous IgE total and specific elevations for the tested fungi, possibly due to polysensitization caused by the presence of fungi in all of the areas all year. However, determining the clinical significance of the results was not yet possible because most of the data were isolated variables.
KEYWORDS: Airborne fungi; IgE; Respiratory allergy
Allergy Asthma ClinImmunol. 2016 Apr 27;12:18.doi:10.1186/s13223-016-0128-y. eCollection 2016.
