亚洲沙尘对日本西部成年哮喘患者肺功能的影响: 一项小组研究
2016/06/20
摘要
背景：亚洲沙尘（AD）已成为一个主要的健康问题。亚洲沙尘的浓度通常用颗粒物低于10μM（PM10）和2.5μM（PM2.5）表示。然而，PM10和PM2.5除了灰尘外还包括各种物质。光探测和测距（LIDAR）系统可以选择性地测量亚洲沙尘颗粒数量来区分非球面大气颗粒物和球形大气颗粒。本研究的目的是使用LIDAR（激光雷达）数据来探讨成人哮喘患者的肺功能与亚洲沙尘的关系。
方法：受试者为231名成人哮喘患者，从2012年三月到五月测量晨间呼气峰流速（PEF）。用线性混合模型来评估PEF与激光雷达探测的沙尘粒子的关系。
结果：亚洲灰尘的粒子四分位数间距范围增大（0.018公里（- 1））导致PEF变化-0.42L/min（95%可信区间[CI]，-0.85-0.01）。悬浮颗粒物增加11.8μg/m(3)、PM2.5增加6.9 μg/m(3)使得PEF分别降低-0.17 L/min (-0.53-0.21)和0.03L/min (-0.35-0.42)。一个严重的亚洲沙尘天气是指一天的亚洲沙尘颗粒水平为>0.032km(-1)，这是在研究期间的平均值加一个标准偏差。确定了6个严重的沙尘天。一个严重的亚洲沙尘天后的PEF变化为-0.97 L/min（-1.90-0.04）。
结论：严重暴露于亚洲沙尘颗粒与成年哮喘患者肺功能下降显著相关。
（苏欣 审校）
Allergol Int. 2016 Apr;65(2):147-52. doi: 10.1016/j.alit.2015.10.002. Epub 2015 Nov 20.
Effect of Asian dust on pulmonary function in adult asthma patients in western Japan: A panel study.
Watanabe M1, Noma H2, Kurai J3, Sano H4, Mikami M5, Yamamoto H6, Ueda Y3, Touge H3, Fujii Y7, Ikeda T8, Tokuyasu H9, Konishi T10, Yamasaki A3,Igishi T3, Shimizu E3.
Author information
Abstract
BACKGROUND:Asian dust (AD) has become a major health concern. The concentration of AD is typically expressed in particulate matter less than 10 μm (PM10) and 2.5 μm (PM2.5). However, PM10 and PM2.5 consist of various substances besides AD. Light detection and ranging (LIDAR) systems can selectively measure the quantity of AD particles to distinguish non-spherical airborne particles from spherical airborne particles. The objective of this study was to investigate the relationship between pulmonary function in adult asthma patients and AD using LIDAR data.
METHODS:Subjects were 231 adult asthma patients who had their morning peak expiratory flow (PEF) measured from March to May 2012. A linear mixed model was used to estimate the association of PEF with sand dust particles detected by LIDAR.
RESULTS:Increases in the interquartile range of AD particles (0.018 km(-1)) led to changes in PEF of -0.42 L/min (95% confidence interval [CI], -0.85 to 0.01). An increase of 11.8 μg/m(3) in suspended particulate matter and 6.9 μg/m(3) in PM2.5 led to decreases of -0.17 L/min (-0.53 to 0.21) and 0.03 L/min (-0.35 to 0.42), respectively. A heavy AD day was defined as a day with a level of AD particles >0.032 km(-1), which was the average plus one standard deviation during the study period, and six heavy AD days were identified. Change in PEF after a heavy AD day was -0.97 L/min (-1.90 to -0.04).
CONCLUSIONS:Heavy exposure to AD particles was significantly associated with decreased pulmonary function in adult asthma patients.
Copyright © 2015 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.
KEYWORDS:Adult asthma; Asian dust; Light detection and ranging; Peak expiratory flow; Sand dust particles
Allergol Int. 2016 Apr;65(2):147-52. doi: 10.1016/j.alit.2015.10.002. Epub 2015 Nov 20.
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