哮喘联盟

   摘要
   背景：哮喘是遗传、种族、环境和社会/生活方式等多种危险因素相互作用的结果。
   目的：本研究的目的是评价儿童哮喘与环境危险因素（二手烟暴露）、养宠物、种族、哮喘家族史之间的关系。
   方法：经伦理委员会(IRB)的同意，2011年6月至2014年12月间共有823例哮喘儿童纳入本前瞻性横断面研究。在初次访视中，根据哮喘家族史、家中养宠物的情况、父母家中抽烟导致二手烟暴露情况由儿童家人填写一项调查问卷。运用x2检验进行分析，α显著性水准为 ≤ 0.05。
   结果：575 (69.8%)例儿童的父母、兄弟姐妹、外/祖父母伴有哮喘病史，其中包括父亲(n = 154, 17.8%)和母亲(n = 235, 26.5%)。伴有哮喘家族史的儿童 (n = 575)家中养有宠物、二手烟暴露的比例（分别为n = 347，占60.3% 及n = 198，占34.4%)显著高于无哮喘家族史的儿童（分别为n = 124，占50%，两者比较 p = 0.006及n = 44，占17.7%，两者比较 p < 0.001）。类似地，二手烟暴露的哮喘儿童(n = 241)家中养有宠物、伴有哮喘家族史的比例（分别为n = 153，占63.5%及n = 197，占81.7%）显著高于无二手烟暴露的儿童（分别为n = 315，占55.5%，两者比较p = 0.034及n = 371，占65.3%，两者比较p < 0.001）。
   结论：直系亲属有哮喘病史的儿童家中养有宠物、二手烟暴露显著高于无哮喘家族史的儿童，提示生活方式/环境暴露与哮喘家族史之间存在关联性。

（杨冬 审校）
J Asthma. 2016 Jan 20:1-6. [Epub ahead of print]

 

Environmental exposures and family history of asthma.
 

Sheikh SI1,2, Pitts J2, Ryan-Wenger NA1,2, McCoy KS1,2, Hayes D Jr1,2,3.
 

Abstract
BACKGROUND:Asthma pathogenesis is a complex interaction of genetic, ethnic, environmental and social/life style risk factors.
AIM:The goal of this study was to identify associations, if any, in children with asthma, between environmental risk factors (exposure to second-hand tobacco smoke (STS), pet ownership, race and a family history of asthma.
METHODS:After IRB approval, from June 2011 to December 2014, 823 children with asthma were enrolled in this prospective cross sectional study. At the initial visit, families completed a questionnaire with information on family history of asthma, having a pet at home and exposure to STS by parents at home. Chi square analyses were calculated, with alpha level of significance ≤0.05.
RESULTS:History of asthma in parents, siblings or grandparents was reported by 575 (69.8%) patients including father (n = 154, 17.8%) and mother (n = 235, 26.5%). Children with family history of asthma (n = 575) were significantly more likely to have a pet at home and exposure to STS (n = 347, 60.3% and n = 198, 34.4%, respectively) compared to families without a history of asthma (n = 124, 50%, p = 0.006 and n = 44, 17.7%, p < 0.001, respectively). Similarly, asthmatic children with exposure to STS (n = 241) were significantly more likely to have a pet at home and a family history ofasthma (n = 153, 63.5% and n = 197, 81.7%, respectively) compared to children with no STS exposure (n = 315, 55.5%, p = 0.034 and n = 371, 65.3%, p < 0.001 respectively).
CONCLUSIONS:Significantly more asthmatic children with immediate relatives with a history of asthma have a pet at home and experience STS exposure compared to children without relatives with a history of asthma, suggesting association between life style choices/environmental exposures and family history of asthma.
 

J Asthma. 2016 Jan 20:1-6. [Epub ahead of print]