哮喘联盟

   摘要
   目的：为了在4-18岁的墨西哥裔美国儿童中测试宫内和初生暴露于猫/狗和鸟，与一生中的医生诊断为哮喘和其他呼吸系统疾病的风险之间的关系。
   方法：这项研究是一个在1816名墨西哥裔美国儿童中基于人群的横断面研究。我们采用多逻辑模型测试哮喘和喘息与宫内、婴儿期和国家出生调查时暴露于猫/狗和鸟的关系，哮喘/过敏家族史，婴儿期抗生素使用和其他因素作为协变量。
   结果：经校正后分析，与宫内未暴露于宠物的儿童相比，宫内暴露于猫/狗和鸟均与哮喘（校正后比值比（aOR）：2.89；95%可信区间（CI）：1.34-6.23）、不停的喘息（aOR：1.96；95%可信区间：1.11-3.46）和当前运动性喘息（aOR：3.16；95% CI：1.27-7.85）风险增加相关，。子宫内暴露于猫/狗和鸟类的儿童目前喘息的发生率升高，尽管统计学无意义。婴儿期和调查时暴露于猫/狗和鸟与哮喘或喘息无关。
   结论：非大样本的墨西哥裔美国儿童调查可知，宫内暴露于宠物可能与哮喘和其他呼吸系统疾病的风险增加有关。

 

（苏欣 审校）
J Asthma. 2016 Jan 21:1-8. [Epub ahead of print]


 

In utero exposure to pets is associated with asthma and wheezing in Mexican American children.
 

Eldeirawi K1, Kunzweiler C2, Combs AM1, Persky VW2.
 

Abstract
OBJECTIVE:To examine the associations of in utero and early life exposure to cats/dogs and birds with the risk of lifetime doctor-diagnosed asthmaand other respiratory conditions in a sample of Mexican American (MA) children 4-18 years of age.
METHODS:This study is a population-based cross-sectional investigation of 1816 MA children. We conducted multiple logistic models examining the relationship of asthma and wheezing with exposures to cats/dogs and birds in utero, infancy and at the time of the survey adjusted for country of birth, family history of asthma/allergies, antibiotics use in infancy and other covariates.
RESULTS:In adjusted analyses, in utero exposure to cats/dogs and birds jointly was associated with increased odds of asthma (adjusted odds ratio (aOR): 2.89; 95% confidence interval (CI): 1.34-6.23), ever wheezing (aOR: 1.96; 95% CI: 1.11-3.46) and current exercise-induced wheezing (aOR: 3.16; 95% CI: 1.27-7.85) compared to children not exposed to these pets in utero. Children who were exposed to both cats/dogs and birds in utero had an elevated, albeit statistically non-significant, odds of current wheezing. Exposures in infancy and at the time of the survey to cats/dogs and birds were not associated with asthma or wheezing.
CONCLUSIONS:In utero exposure to pets might be associated with an increased risk of asthma and respiratory conditions in a sample of non-affluent MA children.
 

J Asthma. 2016 Jan 21:1-8. [Epub ahead of print]