哮喘联盟

   摘要
   背景：几项研究表明，哮喘与卒中风险增加有关。然而，结果不尽相符。本研究的目的是通过对已发表的研究进行系统的回顾和荟萃分析，探讨哮喘和中风风险之间的关系。
   方法：相关研究通过检索截止2015年6月PubMed和科学数据库的数据。专属研究风险比率（HRs）和95%的可信区间（CLs）使用合适的固定效应或随机效应模型。在亚组中，代表不同的参与者和研究特点与哮喘之间的关系进行了测试。发表的偏倚采用Egger测试评估。
   结果：五篇文章，包括524637名参与者和6031名卒中患者符合纳入分析。哮喘与卒中风险增加显著相关，合并的HR为1.32（95%可信区间：1.13，1.54，I2 = 80.4%）。亚组分析显示，哮喘和卒中风险之间的关系在女性患者（HR = 1.42，95%可信区间：1.15-1.76）和前瞻性队列研究设计（HR  = 1.52，95%可信区间：1.21-1.91）中更强。
   结论：哮喘与卒中风险增加显著相关。这一发现可能对于临床和公共卫生有重要意义。

 

（苏欣 审校）
JStrokeCerebrovascDis. 2016Jan20.pii:S1052-3057(15)00655-2.doi:10.1016/j.jstrokecerebrovasdis.2015.11.030. [Epub ahead of print]
 

Asthma and Risk of Stroke: A Systematic Review and Meta-analysis.
 

Wen LY1, Ni H2, Li KS1, Yang HH1, Cheng J1, Wang X1, Zhao DS1, Xie MY1, Su H3.
 

Abstract
BACKGROUND:Several studies have suggested that asthma is associated with an increased risk of stroke. However, the results are inconsistent. The aim of this study is to investigate the relation of asthma and the risk of stroke through a systematic review and meta-analysis of published research.
METHODS:Pertinent studies were identified by a search of the PubMed and the Web of Science databases to June 2015. Study-specific hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using fixed-effect or random-effect models when appropriate. Associations were tested in subgroups representing different participants and study characteristics. Publication bias was assessed with Egger's test.
RESULTS:Five articles comprising 524,637 participants and 6031 stroke cases were eligible for inclusion. Asthma was associated significantly with increased risk of stroke, and the pooled HR was 1.32 (95% CI: 1.13, 1.54, I2=80.4%). Subgroup analyses revealed that the association betweenasthma and stroke risk was stronger among female patients (HR = 1.42, 95% CI: 1.15-1.76) and prospective cohort study design (HR = 1.52, 95% CI: 1.21-1.91).
CONCLUSION:Asthma is associated with a significantly increased risk of stroke. This finding may have clinical and public health importance.
 

JStrokeCerebrovascDis. 2016Jan20.pii:S1052-3057(15)00655-2.doi:10.1016/j.jstrokecerebrovasdis.2015.11.030. [Epub ahead of print]