哮喘联盟

   摘要
   研究目标：研究学龄前儿童哮喘与过敏、家庭环境及父母健康状况的相关性。
   研究方法：在中国重庆地区从任意幼儿园中随机抽取3-6岁儿童的父母进行问卷调查，问卷调查内容包含儿童及父母症状及家庭环境。通过控制性别，年龄，母乳喂养以及父母因素（性别，吸烟率，哮喘，过敏）等因素，本次研究使用多元回归分析方法分析学龄儿童哮喘及过敏与家庭环境的相关性。进一步通过调整父母当前的症状来评估这种相关性。
   研究结果：在4250名儿童中（问卷回收率：74.5%），8.4%为医生诊断哮喘（DDA），6.2%为医生诊断鼻炎（DDR）。在这些儿童的父母中，5.5%的父母有哮喘及过敏史，16.2%是吸烟者。家庭环境湿度分别与儿童DDA（OR=1.72），DDR（OR=2.10），喘息（OR=1.60），咳嗽（OR=1.50），鼻炎（OR=1.39）及湿疹（OR=1.69）相关。交通暴露因素分别与儿童DDA（OR=1.27），DDR（OR=1.54），喘息（OR=1.21），咳嗽（OR=1.24），鼻炎（OR=1.19）相关。目前伴有各种症状的父母，其子女患哮喘及过敏的概率高1.5到2倍。进一步调整父母的健康状况几乎不影响室内潮湿环境与儿童患哮喘及过敏的相关性。
   研究结论：室内潮湿环境与儿童哮喘及过敏症状存在相关性。为了减少报道偏倚引起的儿童哮喘及过敏患病率的误差，父母的健康状况也需要进行分析，尤其是进行生态分析。

 

（南方医科大学南方医院 熊婧 赵海金 ）
2015,ERS Meeting
 

Preschool children’s asthma and allergic symptoms in Chongqing, China, associated with parental health: Reporting bias or shared home environment

Juan Wang, Baizhan Li, Wei Yu, Qin Yang, Han Wang, Jan Sundell, Dan Norback ¹Department of Medical Sciences, Uppsala University, Uppsala, Sweden; ²Key Laboratory of Three Gorges Reservoir Region’s Eco-Environment, Chongqing University, Chongqing, China; ³Department of Building Science, Tsinghua University, Beijing, China
2015,ERS Meeting
PA3406 http://abstract.ersnet.org/my-abstract-book-2015/

Abstract
Aim: To study associations between children’s asthma and allergy, home environment and parental health.
Methods: Parents of 3-6 years old children from randomized kindergartens in Chongqing, China answered a questionnaire (one/child), include questions on children and parents’ symptoms and home environment. Associations between children’s asthma and allergy and the home environment were analysed by multiple logistic regression, controlling for gender, age, breast feeding and parental factors (gender, smoking, asthma and allergy). Additional models were applied with further adjustment for parents’ current symptoms.
Results: Among 4250 children (response rate: 74.5%), 8.4% had doctor-diagnosed asthma (DDA) and 6.2% doctor-diagnosed rhinitis (DDR). Among parents, 5.5% had a history of asthma and allergies and 16.2% were smokers. Home dampness was associated with children’s DDA (OR=1.72), DDR (OR=2.10), wheeze (OR=1.60), cough (OR=1.50), rhinitis (OR=1.39) and eczema (OR=1.69). Traffic exposure was associated with children’s DDA (OR=1.27), DDR (OR=1.54), wheeze (OR=1.21), cough (OR=1.24), and rhinitis (OR=1.19). Parents with different types of current symptoms reported 1.5-2 times more asthma and allergy among their child. Further adjustment for parents’ health status had little influence on the ORs for associations between dampness and children’s asthma and allergy.
Conclusions: Consistent associations between home dampness and children’s asthma and allergy were found. Reporting bias could influence prevalence of children’s asthma and allergy, and adjustment for parental health can be needed, especially in ecological analysis.