哮喘联盟

   摘要
   研究背景：研究表明，哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)患者承受巨大疾病负担。然而，在中国这个呼吸道疾病流行病学变化迅速的地区，很少有关于ACOS的研究。
   研究目的：评价中国城市ACOS与患者预后的关联性。
   研究方法：数据来自于2010、2012和2013年中国国家卫生和健康调查（N=59,935），该调查是一项针对于中国地区成年人的网络调查。根据受调查者自诉发病时的医师诊断，将其分为4组：ACOS(诊断哮喘+慢阻肺）组、哮喘组、慢阻肺组及对照组（非哮喘或慢阻肺）组。通过采取倾向得分匹配(PSM)方法校正对照组。最后对这四个分组的健康状况(SF-12v2 / SF-36v2)、工作效率（以损失工作时间百分比形式计算）以及所使用的医疗资源用广义线性模型作比较。
   研究结果：在国家卫生与健康调查中发现0.61%成年人患有ACOS；其中哮喘与慢阻肺患者中，分别有30.73%和18.60%患有ACOS。而且ACOS患者的疾病负担最大（P<0.05)。与匹配对照组及单纯慢阻肺患者相比，ACOS患者的疾病预后明显更差。而ACOS患者与单纯哮喘患者相比无显著差异。
   研究结论：与单纯慢阻肺及对照组相比，ACOS患者承担更大疾病负担且疾病预后更差。
 

（南方医科大学南方医院 赵文驱 赵海金 ）
   2015,ERS Meeting

 

The burden of asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) in urban China

Bo Ding, Marco DiBonaventura, Jonas Roman, Niklas Karlsson, Xia Ling
¹Global Medicines Development, AstraZeneca, Mlndal, Sweden; ²Health Outcomes Practice, Kantar Health, New York, United States; ³Global Commercial - China, AstraZeneca, Shanghai, China
Introduction:
2015,ERS Meeting
PA4065
http://abstract.ersnet.org/my-abstract-book-2015/

Abstract
Background: Research has suggested a significant burden for patients with asthma-COPD overlap syndrome (ACOS). However, few studies have studied ACOS in China, a region in the midst of rapid epidemiological change with respect to respiratory disease.
Objectives: To assess the association between ACOS and patient outcomes in urban China
Methods:Data from the 2010, 2012, and 2013 China National Health and Wellness Survey, an Internet-based survey of adults in urban China, were used (N=59,935). Respondents were categorized based on self-reported physician diagnosis into one of four groups: ACOS (i.e., reporting both an asthma and COPD diagnosis), asthma only, COPD only, or control (i.e., no asthma or COPD). A propensity score matching procedure was conducted to cull the control group into a group of matched controls. These four groups were then compared with respect to health status (SF-12v2/SF-36v2), work productivity (measured by percentage of work time lost), and healthcare resource use using generalized linear models.
Results: 0.61% of all adults in NHWS had ACOS (N=366); 30.73% and 18.60% of those with asthma and COPD, respectively, had ACOS. ACOS patients had the greatest comorbidity burden (p<.05). ACOS patients reported significantly worse health outcomes compared with matched controls and COPD only patients. Few significant differences were observed between ACOS and asthma only patients.
Conclusions: ACOS patients have a greater comorbidity burden and significantly worse health outcomes compared with COPD only patients and matched controls