哮喘联盟

   摘要
   产前应激不利于母体健康，也会对后代产生负面影响，这同样适用于妊娠期间的母体应激。然而，产前母体应激是否会增加子代哮喘发生的风险尚不明确，本文将对此进行评估。来自小鼠模型的证据表明：妊娠期间的母体应激使子代患哮喘的风险增加。虽然最近的实验室研究增加了支持产前母体应激与子代哮喘风险之间存在因果关系的证据，但仍缺乏充足的流行病学论据。几乎所有现有的观察性研究都存在严重的方法学缺陷。尽管如此，关于妊娠期间的母体应激与子代哮喘风险的实验室研究结果，与对子代产生的其他显著的不良影响相一致，足以证明减少产前特别是妊娠期间母体应激的合理性。

 

（苏欣 审校）
Expert Rev Respir Med. 2015 Jul 11:1-3. [Epub ahead of print]

 

Can prenatal maternal stress increase the risk of asthma?
 

Heinrich J1.
 

Abstract
Maternal stress adversely affects a mother's well-being and health and also negatively impacts her offspring. That this relationship also holds true for maternal stress during the pregnancy period is intuitive. However, whether maternal stress increases the risk of asthma development in her offspring is less clear and will be evaluated in this review. There is evidence from murine models to suggest that maternal stress during pregnancy increases the risk of asthma in the offspring. While recent experimental research adds to the increasing body of evidence supporting a causal relationship between prenatal maternal stress and asthmarisk in the offspring, the epidemiological evidence supporting this notion is insufficient. Almost all existing observational studies suffer from severe methodological limitations. Nevertheless, the results from experimental work on maternal stress during pregnancy and asthma risk in the offspring, in concert with other obvious adverse health effects in the offspring are sufficient to justify a recommendation to reduce maternal stressors, particularly during pregnancy.
 

Expert Rev Respir Med. 2015 Jul 11:1-3. [Epub ahead of print]