哮喘联盟

   摘要
   背景:动物过敏是儿童哮喘的一个主要决定因素。未选择儿科诊治人群的成分分析研究是缺乏的。本研究旨在分析对动物过敏的学龄儿童中，动物成分引起的致敏作用与哮喘和鼻炎的关系。
   方法:从一个基于瑞典人的队列中随机抽取696名儿童 (11～12岁) ，采用 ImmunoCAP过敏原检测系统检测他们对猫、狗、马的皮屑的敏感性。对动物过敏的儿童进一步做血清分析，采用包含了三种来源于猫、四种来源于狗、两种来源于马的过敏原成分的芯片进行分析。 由父母完成ISAAC扩展问卷。
   结果:对动物过敏的259名儿童中 (≥0.1 kUA /L), 51% 对三种动物均过敏，23% 对两种动物过敏，25%对一种动物过敏。当前哮喘和接触猫后的哮喘症状与Fel d1蛋白和Fel d4蛋白的共敏有关。 这种相关性已被认为是对Fel d 4中等程度敏感的(1-15 ISU) 的情况下，大多儿童对 Fel d 1也敏感。在对狗过敏的儿童中大多数对不止一种狗成分敏感，,对 Can f 5 和Can f 1/f 2 的共敏化是患哮喘最大的风险。对高度可交叉反应的血清白蛋白敏感并不常见，并且不与哮喘相关。
   结论:在瑞典北部的小学生中, 螨虫过敏很罕见,而毛皮动物是主要的致敏剂。哮喘与更高水平的成分致敏作用有关，对来源同一种动物的多种成分敏感是患哮喘的最大风险。
 

（苏欣 审校）
Pediatr Allergy Immunol. 2015 Jun 9. doi: 10.1111/pai.12422. [Epub ahead of print]

 

A population-based study of animal component sensitization, asthma and rhinitis in schoolchildren.
 

Bjerg A1,2, Winberg A3, Berthold M4, Mattsson L4, Borres MP4,5, Rönmark E1,2.

Abstract
BACKGROUND:Animal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren.
METHODS:A random sample of 696 children (11-12 y) from a Swedish population-based cohort was tested for sensitization to cat, dog and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog and two from horse. The parents completed an expanded ISAAC questionnaire.
RESULTS:Of 259 animal-sensitized children (≥0.1 kUA /L), 51% were sensitized to all three, 23% to two and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma.
CONCLUSIONS:Among schoolchildren in Northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk. This article is protected by copyright. All rights reserved.
 

Pediatr Allergy Immunol. 2015 Jun 9. doi: 10.1111/pai.12422. [Epub ahead of print]