咳嗽与阻塞性睡眠呼吸暂停
2015/08/18
摘要
最新报道指出阻塞性睡眠呼吸暂停（OSA）是慢性咳嗽的原因之一。当咳嗽经过检查和针对普通原因的治疗后仍然无法得到缓解和解释时，应考虑OSA的可能。夜间咳嗽、打鼾和胃食管反流可能有助于确定患者是否需要进行进一步的调查。白天嗜睡通常不会发生。持续的气道正压治疗（CPAP）能有效缓解咳嗽。如果患者有胃食管反流疾病，治疗应该给予优化。OSA和咳嗽之间的关联机制尚不明确，但气道炎症、胃食管反流性疾病、咳嗽反射的高敏感性，气管支气管软化症是可能的解释。进一步的研究应建立OSA-咳嗽的临床预测方法，探索机制和最佳治疗方案。
（苏欣 审校）
Pulm Pharmacol Ther. 2015 Jun 9. pii: S1094-5539(15)00065-6. doi: 10.1016/j.pupt.2015.05.008. [Epub ahead of print]
Cough in obstructive sleep apnoea.
Chan K1, Ing A2, Birring SS3.
Author information
Abstract
Obstructive Sleep Apnoea (OSA) has recently been reported to be a cause of chronic cough. It should be considered when cough remains unexplained following investigations and treatments for common causes. The presence of nocturnal cough, snoring and gastro-oesophageal reflux may be helpful in identifying patients who require further investigation. Daytime somnolence is often absent. Continuous positive airway pressure (CPAP) therapy has been reported to be effective in alleviating cough. Therapy for gastro-oesophageal reflux disease, if present, should be optimised. The mechanism of the association between OSA and cough is not clear, but airway inflammation, gastro-oesophageal reflux disease, increased cough reflex sensitivity and tracheobronchomalacia are possible explanations. Further studies should identify clinical predictors of OSA-cough, establish mechanisms and the optimal therapy.
Pulm Pharmacol Ther. 2015 Jun 9. pii: S1094-5539(15)00065-6. doi: 10.1016/j.pupt.2015.05.008. [Epub ahead of print]
