咳嗽由神经元的Na+-K+-ATP酶调控
2015/08/18
摘要
Na+-K+-ATP酶在细胞兴奋时，建立细胞内外钠离子浓度梯度发挥着重要的作用。钠离子泵的多个亚型已经鉴定，具有组织和细胞特异性表达模式。由于调控咳嗽的迷走传入神经需要持续高频率动作电势的刺激以达到激发咳嗽的阈值，可以确定钠离子泵功能对于健康或患病时保持咳嗽反射敏感性是必不可少的。本文通过回顾调查Na+-K+-ATP酶调节支气管肺迷走传入神经兴奋性的机制，以及将钠离子泵作为咳嗽治疗靶点的潜在治疗策略。
（苏欣 审校）
Curr Opin Pharmacol. 2015 Jun 2;22:140-145. doi: 10.1016/j.coph.2015.05.002. [Epub ahead of print]
Regulation of cough by neuronal Na+-K+ ATPases.
Canning BJ1, Farmer DG2.
Author information
Abstract
The Na+-K+ ATPases play an essential role in establishing the sodium gradients in excitable cells. Multiple isoforms of the sodium pumps have been identified, with tissue and cell specific expression patterns. Because the vagal afferent nerves regulating cough must be activated at sustained high frequencies of action potential patterning to achieve cough initiation thresholds, it is a certainty that sodium pump function is essential to maintaining cough reflex sensitivities in health and in disease. The mechanisms by which Na+-K+ ATPases regulate bronchopulmonary vagal afferent nerve excitability are reviewed as are potential therapeutic strategies targeting the sodium pumps in cough.
Curr Opin Pharmacol. 2015 Jun 2;22:140-145. doi: 10.1016/j.coph.2015.05.002. [Epub ahead of print]
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呼出和鼻腔一氧化氮评估慢性咳嗽的扩展分析
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咳嗽与阻塞性睡眠呼吸暂停
