哮喘联盟

   摘要
   背景：患者相关的预后标准对高质量的临床研究至关重要，而生活质量（QoL）工具是当前的标准。目前，还没有有效的儿童急性咳嗽特异性生活质量调查问卷。
   目的：此项研究旨在开发和验证父母代理的儿童急性咳嗽特异性生活质量调查问卷（PAC-QoL）
   方法：使用焦点小组，开发一个48项的PAC-QoL问卷，后来利用临床影响方法减少到16项。入学时有急性咳嗽（< 2周）的儿童父母完成2项有效的咳嗽评分措施，初步的48项PAC-QoL和3项其他问卷（状态-特质焦虑量表[STAI]，短式的8项-24小时召回的健康调查[SF-8]和抑郁、焦虑和压力21项量表[DASS21]），在第3天和第14天重复上述所有措施。
   结果：155例入学儿童的平均年龄为2.3岁（四分位间距，1.3-4.6），平均咳嗽持续时间为3天（四分位间距，2-5）。简化的16项量表具有较高的内部一致性(克伦巴赫α=0.95)。通过第0天和第3天的域和总PAC-QoL评分和SF-8（r=0.36和-0.51）、STAI（r = -0.27和 -0.39），及DASS21（r = -0.32 和 -0.41）量表的显著相关性来证实此量表的可重复性和标准有效性。最终的PAC-QoL问卷对时间的变化敏感，并随咳嗽评分措施的变化显著改变（p<0.001）
   结论：16项PAC-QoL是一项可靠和有效的预后评估措施，能在特定的时间点评估急性咳嗽儿童的生活质量，并反映急性咳嗽特异性生活质量随时间的变化。
 

(苏欣 审校)
JAllergyClinImmunol. 2015May;135(5):1179-1185.e4.doi:10.1016/j.jaci.2014.08.036. Epub 2014 Oct 31.

An acute cough-specific quality-of-life questionnaire for children: Development and validation.
 

Anderson-James S1, Newcombe PA2, Marchant JM3, O'Grady KA4, Acworth JP5, Stone DG6, Turner CT7, Chang AB8.

Abstract
BACKGROUND:Patient-relevant outcome measures are essential for high-quality clinical research, and quality-of-life (QoL) tools are the current standard. Currently, there is no validated children's acute cough-specific QoL questionnaire.
OBJECTIVE:The objective of this study was to develop and validate the Parent-proxy Children's Acute Cough-specific QoL Questionnaire (PAC-QoL).
METHODS:Using focus groups, a 48-item PAC-QoL questionnaire was developed and later reduced to 16 items by using the clinical impact method. Parents of children with a current acute cough (<2 weeks) at enrollment completed 2 validated cough score measures, the preliminary 48-item PAC-QoL, and 3 other questionnaires (the State Trait Anxiety Inventory [STAI], the Short-Form 8-item 24-hour recall Health Survey [SF-8], and the Depression, Anxiety, and Stress 21-item Scale [DASS21]). All measures were repeated on days 3 and 14.
RESULTS:The median age of the 155 children enrolled was 2.3 years (interquartile range, 1.3-4.6). Mediancough duration at enrollment was 3 days (interquartile range, 2-5). The reduced 16-item scale had high internal consistency (Cronbach α = 0.95). Evidence for repeatability and criterion validity was shown by significant correlations between the domains and total PAC-QoL scores and the SF-8 (r = -0.36 and -0.51), STAI (r = -0.27 and -0.39), and DASS21 (r = -0.32 and -0.41) scales on days 0 and 3, respectively. The final PAC-QoL questionnaire was sensitive to change over time, with changes significantly relating to changes in cough score measures (P < .001).
CONCLUSION:The 16-item PAC-QoL is a reliable and valid outcome measure that assesses QoL related to childhood acute cough at a given time point and reflects changes in acute cough-specific QoL over time.

JAllergyClinImmunol. 2015May;135(5):1179-1185.e4.doi:10.1016/j.jaci.2014.08.036. Epub 2014 Oct 31.