哮喘联盟

   摘要
   吸烟不利于多发性硬化症（MS）的预后。我们的研究表明，吸烟的MS患者吲哚胺2,3-双加氧酶活性降低，导致IL-6和IL-13增加。此外，在吸烟的MS患者中表达度和肾素-血管紧张素系统的活性水平均升高，可增加IL-17和IL-22分泌细胞的数量以及大量释放单核细胞趋化因子CCL2，CCL3和CXCL10。最后，两个途径促使了吸烟的MS患者CD4+ CD25+ Foxp3 +调节性T细胞数量显著下降。这两种途径可能是吸烟和MS风险两者间关联的原因。
 

（苏欣 审校）
J Neuroimmunol. 2015 Apr 15;281:23-34. doi: 10.1016/j.jneuroim.2015.03.006. Epub 2015 Mar 6.

 

Smoking worsens multiple sclerosis prognosis: Two different pathways are involved.
 

Correale J1, Farez MF2.

Author information
 

Abstract
Smoking worsens multiple sclerosis (MS) prognosis. Our study provides evidence that indoleamine 2,3-dioxygenase activity is reduced in MS patients who smoke, leading to increased production of IL-6 and IL-13. Additionally, both degree of expression and renin-angiotensin system activity levels were increased in MS patients who smoked, inducing increase in IL-17 and IL-22-producing cell numbers as well as significantly greater production of CCL2, CCL3 and CXCL10 chemokines by monocytes. Finally, both pathways contributed to a significant decrease in the number of CD4+CD25+FoxP3+ regulatory T cells in MS patients who smoked. Both pathways could be responsible for the association between smoking and MS risk.
 

J Neuroimmunol. 2015 Apr 15;281:23-34. doi: 10.1016/j.jneuroim.2015.03.006. Epub 2015 Mar 6.