哮喘联盟

   摘要
   简介：虽然妊娠期接触烟草烟雾的风险已经确立，但很少有研究阐述儿童早期家庭烟雾暴露对代谢的危害。本研究目的是前瞻性考察儿童早期家庭烟雾暴露和10岁时两项肥胖指标之间的长期关系。
   方法：来自Quebec儿童发育纵向研究出生队列的参与者在四个时间点（从1岁到7岁）被分到了三组儿童早期家庭烟雾暴露中的一组。三组分别为：从不暴露，短暂暴露，连续暴露。而肥胖指标BMI和腰围，在10岁时独立进行评估。
   结果：相比于从不暴露，短暂暴露和连续家庭烟雾暴露儿童的腰围指标增加分别为0.93厘米（95％CI，0.05-1.82厘米；P = 0.03）和1.56厘米（95％CI，0.07-3.05厘米；P = 0.04）。相比于从不暴露，短暂暴露和连续家庭烟雾暴露儿童体重指数增加分别为0.48和0.81，P值均为0.005。如果中途纠正，变量模糊后，只有短暂家庭烟雾暴露有43％的几率超重/肥胖（95％CI，1.12-1.81；P <0.01）。
   结论：我们发现以家庭二手烟雾暴露和不健康的身体脂肪分布之间有显著的长期潜在关系。青年腰围已经成为成年肥胖相关疾病的重要危险素。我们的研究结果强调公众健康的重要性，提高家长的敏感性，以减少儿童成长关键时期的家庭烟雾暴露。

 

（苏欣 审校）
 Nicotine Tob Res. 2015 Jun 11. pii: ntv128. [Epub ahead of print]


 

Prospective associations between early long-term household tobacco smokeexposure and subsequent indicators of metabolic risk at age 10.
 

Pagani LS1, Nguyen AK2, Fitzpatrick C3.

Author information
 

Abstract
INTRODUCTION:Although there are established risks associated with gestational tobacco smoke exposure, few studies have addressed the metabolic hazards of domestic exposure in early childhood. This study prospectively examines the long-term relationship between early childhood exposure to household smoke and two adiposity-related measures at age 10.
METHODS:Participants from the Quebec Longitudinal Study of Child Development birth cohort were categorized into one of three groups of early childhood household exposure to tobacco smoke over four time points (from ages 1 to 7 years): never-exposed; transient exposure; and continuous exposure. Follow-up measures of BMI and waist circumference were independently assessed at age 10.
RESULTS:Compared to being never exposed, transient and continuous household smoke exposure predicted increases of 0.93 cm (95% CI, 0.05-1.82 cm; p = .03) and 1.56 cm (95% CI, 0.07-3.05 cm; p = .04) in children's waist circumference, respectively. Children exposed to transient and continuous household smoke, compared to unexposed children, also showed .48 and .81 point increases in their BMI respectively, both Ps = .005. Once adjusted, for confounding variables, only transient household smoke remained associated with 43% greater odds of belonging to the overweight/obese category (95% CI, 1.12-1.81; p<.01).
CONCLUSIONS:We found significant long-term prospective associations between home-based secondhandsmoke exposure and unhealthy body fat distribution. Waist circumference in youth has become an important risk factor for obesity-related diseases in adulthood. Our findings emphasize the importance public health initiatives and parental sensitization aimed at domestic exposure reductions during the critical early childhood years.
 

Nicotine Tob Res. 2015 Jun 11. pii: ntv128. [Epub ahead of print]