哮喘联盟

   摘要
   研究目的：特应性皮炎（AD）是皮肤的一种慢性炎症性疾病，主要发生于青少年。虽然关于AD患儿发生哮喘危险因素的研究已存在，但是很多方面仍然需要进一步探索。本研究的目的是调查99例早发型、IgE介导AD学龄患儿发生哮喘的可能危险因素。
   方法：对所有患儿进行临床评估：在入学前的两次不同时间（t1和 t2）检测总体和一组吸入性和食物源性过敏原的特异性IgE；哮喘的诊断评估是在学龄期（t3）随访时进行。
   结果：在t3, 39%的患儿出现哮喘。不同变量间进行比较发现，在t2（平均年龄30个月）时对一种以上的吸入性过敏原敏感与哮喘发生相关，并且草类（(OR 3.24, p=0.020）和猫（OR 2.74, p=0.043）致敏为哮喘发生的独立危险因素。
   结论：早发型AD患儿，2-3岁时的致敏类型可以反映哮喘发生的危险。因此，对于此类患儿，推荐进行更多常见过敏原的检测，以评估特应性疾病的进展。
 

（苏欣 审校）
J Asthma. 2014 Nov 11:1-23. [Epub ahead of print]


 

Patterns of aeroallergen sensitization predicting risk for asthma in preschool children with atopic dermatitis.
 

Calamelli E1, Ricci G, Neri I, Ricci L, Rondelli R, Pession A, Patrizi A.
 

ABSTRACT
OBJECTIVE: Atopic dermatitis (AD) is a chronic inflammatory skin disorder mostly affecting young children. Although several studies aimed to identify the risk factors for asthma in AD children, many aspects still need to be clarified. The aim of this study was to investigate the possible risk factors for asthma at school age in 99 children with early-onset and IgE-mediated AD.
METHODS: All children performed clinical evaluation and total and specific IgE assay for a panel of inhalant and food allergens at two different times (t1 and t2) during pre-school, and asthma diagnosis was assessed at one follow-up visit (t3) at school age.
RESULTS: At t3, 39% of children had developed asthma. Of the variables compared, the sensitization to more than one class of inhalant allergens at t2 (mean age 30 months) was associated with asthma, with grass (OR 3.24, p=0.020) and cat sensitization (OR 2.74, p=0.043) as independent risk factors.
CONCLUSIONS: The sensitization pattern of a child with early-onset AD, also within the first 2-3 years of life, can reflect his risk to develop asthma. Therefore, testing these children for the more common allergens during this time frame should be recommended to predict the evolution of atopic diseases.
 

J Asthma. 2014 Nov 11:1-23. [Epub ahead of print]