哮喘联盟

   摘要
   研究背景：在西方国家，基于临床的研究显示迟发性哮喘患者比早发性哮喘患者病情更严重。然而，老年人群的哮喘发生率是否高于年轻人仍不确定。在亚洲人群中缺乏该基本资料。
   方法：2004年纳入来自94所初级和高级学校学龄儿童的父母作为受试者。横断面自我评估调查表由儿童带给他们父母，以评估父母的呼吸系统健康状况。本项研究调查了不同年龄段典型哮喘症状的发生情况，以及首次哮喘发作后的缓解或复发情况。受试者开展调查时的年龄（人-年）作为分母。
   结果：在949807总人-年的25377例受试者中，860例报告曾发生哮喘。发病高峰年龄段分别在0～12和36～40岁。男性在青春期前哮喘发病率高，女性青春期后发病率高，男性和女性的总体哮喘发病率分别为1.00/1000人-年和0.77/1000人-年。晚发的哮喘患者（首次发病年龄大于12岁）占成人哮喘人群的主体。早发哮喘患者（首次发病年龄小于12岁）中超过52%的患者为持续性或复发性哮喘。年轻人群与年老人群相比哮喘发病率有更显著的晚高峰。
   总结:在亚洲人群中，哮喘发生率与年龄的分布呈U型曲线，在30岁左右出现第二个发病高峰。早发哮喘患者复发的比例高，多数迟发哮喘患者出现哮喘持续状态和成人后复发。
 

(苏欣 审校)
Respir Res. 2014 Nov 12;15(1):135. [Epub ahead of print]


 

Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan.
 

Wu TJ, Wu CF, Lee Y, Hsiue TR, Guo Y.
 

ABSTRACT
BACKGROUNDIN:western countries, late-onset asthmatics are more severe than early-onset asthmatics in clinic-based studies. However, whether asthma occurrence rates were higher in late ages than in younger ages was inconclusive. This information is essentially lacking in Asian population.
METHODS:The participants were schoolchildren¿s parents recruited from 94 elementary and middle schools in 2004. A cross-sectional self-administered questionnaire was sent through the children to their parents to survey their respiratory health. We investigated typical asthma symptoms occurring at different ages and subsequent remission or relapse after the first asthma event. Person-years of the participants from birth to the time of survey were used as the denominator.
RESULTS:Among the 25,377 participants consisting of 949,807 total person-years, 860 reported ever having asthma. Highest incidences occurred at ages 0¿12 and 36¿40 years. The incidence of asthma was higher in males before puberty, and higher in females after puberty, with overall incidences 1.00 and 0.77 per 1000 person-years for females and males, respectively. Participants with late-onset asthma (onset age >12 years) comprised a large portion of adult current asthmatics. More than 52% of persistence or relapse was observed in early-onset asthma (onset age ¿12 years). The younger birth cohort had a more prominent later peak of asthma incidence than the older one.
CONCLUSIONS:Asian population, asthma occurrence showed a U-shape age distribution with a prominent second peak in the thirties. A high proportion of early-onset asthma relapsed and most of late-onset asthma persisted or relapsed in adulthood.
 

Respir Res. 2014 Nov 12;15(1):135. [Epub ahead of print]