哮喘联盟

   摘要
   咳嗽是一种复杂的呼吸系统的行为，它对气道保护非常重要，具有感观属性、机动属性、情感属性和认知属性。因此，咳嗽行为所涉及的神经回路远远超过一个简单的延脑桥反射弧，其包括了一系列广泛分步于脑皮质及皮质下的神经网络。有研究表明，大脑中一些离散的区域反应可能会引发感知器官的识别过程、自发的或紧急情况下的咳嗽控制机制，以及气道刺激和咳嗽后的情感反应。以上研究的成果均提出将中枢神经系统作为咳嗽干预治疗的一个可能靶点。与此一致，对临床上各种各样咳嗽控制障碍的仔细评估显示，咳嗽障碍患者的治疗需要开发更多样化的治疗方案。在本文中，我们详细地对这些观点进行探讨，以指出一些尚未解决的问题并促进对咳嗽未来研究方向的讨论。
 

（刘国梁 审校）
NeurosciBiobehavRev.2014Oct6.pii:S0149-7634(14)00245-0.doi:10.1016/j.neubiorev.2014.09.018. [Epub ahead of print]

 

Cough-related neural processing in the brain: A roadmap for cough dysfunction?
 

Ando A1, Farrell MJ2, Mazzone SB3.
 

ABSTRACT
Cough is a complex respiratory behavior essential for airway protection, consisting of sensory, motor, affective and cognitive attributes. Accordingly, the cough neural circuitry extends beyond a simple pontomedullary reflex arc to incorporate a network of neurons that are also widely distributed throughout the subcortical and cortical brain. Studies have described discrete regional responses in the brain that likely give rise to sensory discriminative processes, voluntary and urge-related cough control mechanisms and aspects of the emotive responses following airways irritation and coughing. Data from these studies highlight the central nervous system as a plausible target for therapeutic intervention and, consistent with this, a careful appraisal of the many and varied clinical disorders of coughing control would argue that more diversified therapies are needed to treat patients with cough dysfunction. In this paper we explore these concepts in detail to highlight unanswered questions and stimulate discussion for potential research of cough in the future.
 

NeurosciBiobehavRev.2014Oct6.pii:S0149-7634(14)00245-0.doi:10.1016/j.neubiorev.2014.09.018. [Epub ahead of print]