哮喘联盟

   摘要
   背景：根据澳大利亚指南，蜂蜜被推荐用以治疗儿童非特异性急性咳嗽。目前已进行的随机对照临床试验大多研究晚上单剂量服用蜂蜜的疗效，但是多剂量服用蜂蜜的疗效仍然是未知的。
   目的：本研究旨在评估连续三个晚服用野花蜂蜜的治疗方法，与右美沙芬（DM）以及左羟丙哌嗪（LDP）相比（两者均为意大利最常用的非处方止咳药）对治疗儿童非特异性急性咳嗽的疗效。
   方法：134例患有非特异性急性咳嗽的儿童被随机分为三组，分别给予连续三个晚上蜂蜜治疗（90ml牛奶+10ml蜂蜜）或与年龄相符剂量的右美沙芬或左羟丙哌嗪。三种治疗方法的疗效通过咳嗽问卷来评估（由患者父母完成）。主要的研究终点指标为治疗成功，定义为治疗后咳嗽问卷调查所得的分数比治疗前降低50%以上。
   结果：由于3个患儿的父母未能完成问卷调查，其数据被剔除。蜂蜜和牛奶治疗组的成功率为80%，非处方止咳药治疗组的成功率为87%（p=0.25）。
   结论：用蜂蜜和牛奶治疗儿童非特异性急性咳嗽的效果与非处方止咳药间无明显差别。虽然本研究未排除安慰剂效应，但结果与以往的研究结果相符，均显示蜂蜜对儿童非特异性急性咳嗽有较好的疗效。
 

（刘国梁 审校）
AllergolImmunopathol(Madr).2014Sep5.pii:S0301-0546(14)00129-3.doi:10.1016/j.aller.2014.06.002. [Epub ahead of print]

 

Effect of multiple honey doses on non-specific acute cough in children. An open randomised study and literature review.
 

Miceli Sopo S1, Greco M2, Monaco S2, Varrasi G3, Di Lorenzo G4, Simeone G5; for the Milk Honey Study (M&HS) Group.
 

ABSTRACT
BACKGROUND: Honey is recommended for non-specific acute paediatric cough by the Australian guidelines. Current available randomised clinical trials evaluated the effects of a single evening dose of honey, but multiple doses outcomes have never been studied.
OBJECTIVES: To evaluate the effects of wildflower honey, given for three subsequent evenings, on non-specific acute paediatric cough, compared to dextromethorphan (DM) and levodropropizine (LDP), which are the most prescribed over-the-counter (OTC) antitussives in Italy.
METHODS: 134 children suffering from non-specific acute cough were randomised to receive for three subsequent evenings a mixture of milk (90ml) and wildflower honey (10ml) or a dose of DM or LDP adjusted for the specific age. The effectiveness was evaluated by a cough questionnaire answered by parents. Primary end-point efficacy was therapeutic success. The latter was defined as a decrease in cough questionnaire score greater than 50% after treatment compared with baseline values.
RESULTS: Three children were excluded from the study, as their parents did not complete the questionnaire. Therapeutic success was achieved by 80% in the honey and milk group and 87% in OTC medication group (p=0.25).
CONCLUSIONS: Milk and honey mixture seems to be at least as effective as DM or LDP in non-specific acute cough in children. These results are in line with previous studies, which reported the health effects of honey on paediatric cough, even if placebo effect cannot be totally excluded.
 

AllergolImmunopathol(Madr).2014Sep5.pii:S0301-0546(14)00129-3.doi:10.1016/j.aller.2014.06.002. [Epub ahead of print]