哮喘联盟

   摘要
   背景和目的：许多研究已经评估了β2肾上腺素能受体(ADRB2)基因多态性和哮喘风险的关系。然而，结果是不一致的。本研究对至少3项相关的病例-对照研究进行了荟萃分析，探讨了哮喘与所有ADRB2多态性之间的相关性。
   方法：通过PubMed，Embase，Web of Science，CNKI和万方数据库进行文献检索。使用95%置信区间的比值比来评估关联性的优势。
   结果：46个项病例对照研究鉴定出了Arg16Gly、Gln27Glu、Thr164Ile和 Arg19Cys 单核苷酸多态性(SNPs)。结果显示，在所有的人群中并非所有的SNPs与哮喘相关。在种族划分的分层分析中通过显性模型发现在美国南方人群中的Arg16Gly多态性间的显著差异(OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, 研究数= 2, 病例组= 314, 对照组 = 237)。对于Gln27Glu基因多态性，在儿童中通过隐性模型比较(OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, 研究数  = 11, 病例组= 1693, 对照组 =  502)、纯合子基因型比较(OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, 研究数 = 11, 病例组 = 1693, 对照组= 1502)和在成人中通过显性模型比较(OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, 病例组 = 3160, 对照组 = 3433)发现保护性关联。
   结论：在普通人群中跨族群没有一个ADRB2基因多态性与哮喘风险之间存在可重复的相关性。
 

（林江涛 审校）
PLoS One. 2014 Aug 11;9(8):e104488. doi: 10.1371/journal.pone.0104488. eCollection 2014

 

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies.
 

Liang SQ, Chen XL, Deng JM, Wei X, Gong C, Chen ZR, Wang ZB.
 

ABSTRACT
BACKGROUND AND OBJECTIVE: A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.
METHODS:A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.
RESULTS:Arg16Gly,Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies  = 2, case  = 314, control  = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies  = 11, case  = 1693, control  =  502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies  = 11, case  = 1693, control  = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case  = 3160, control  = 3433).
CONCLUSIONS: None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.
 

PLoS One. 2014 Aug 11;9(8):e104488. doi: 10.1371/journal.pone.0104488. eCollection 2014