哮喘联盟

   摘要
   目的：调查哮喘患者咽喉部症状的发作频率及严重程度，并描述之前未报道过的哮喘并发症----咽喉反流病。
   试验方法：共72人入组，包括36名哮喘患者及36名对照。人群的年龄、性别、哮喘病情、类固醇吸入剂使用情况、吸烟史及过敏史均被记录。13名入组人员进行了肺功能测试。评估内容包括由Belafsky等人描述的反流症状指数。两组人员的各种咽喉部症状均被记录为总分数、发作频率及平均分数。
   结果：哮喘患者的平均年龄为46.61±17.59岁，男女比例为2.3：1。20名患者正在使用类固醇吸入剂。近三分之一（30.6%）为吸烟者，55.6%有过敏性鼻炎。36%的患者哮喘病情得到控制，而剩余的64%其哮喘病情则未能受到控制。与对照组相比，哮喘组总反流症状指数平均值明显升高（6.64 ± 6.08对12.03±8.3, p<0.05）。在哮喘组中，15名患者反流症状指数为阳性，而对照组只有4名（p=0.003）。哮喘组与对照组间共有四种咽喉部症状的患病率和平均分数存在显著差异。
   结论：与对照相比，咽喉反流病在哮喘患者中更加普遍且症状更加严重。
 

（刘国梁 审校）
Clin Respir J. 2014 Jul 3. doi: 10.1111/crj.12179. [Epub ahead of print]

 

Laryngopharyngeal symptoms in patients with asthma; A cross-sectional controlled study.
 

Hamdan AL1, Jaffal H, Btaiche R, Turfe ZA, Bawab I, Kanj N.
 

ABSTRACT
OBJECTIVE: To examine the frequency and severity of laryngopharyngeal symptoms in asthmatic patients. The role of laryngopharyngeal reflux disease as a co-morbid disease to asthma has not been previously reported.
SUBJECTS AND METHOD: Seventy Two subjects, 36 asthmatics and 36 controls were included in this study. Demographic data included age, gender, status of asthma, use of steroid inhalers, smoking and history of allergy. Pulmonary Function Test was reported in 13 subjects. The evaluation consisted of filling the Reflux symptom Index RSI described by Belafsky et al. The total score, frequency and average score of each laryngopharyngeal symptom was computed in both groups.
RESULTS: The mean age of patients was 46.61 years ±17.59 years with a female to male ratio of 2.3:1. Twenty patients were using steroid inhalers. Close to one third were smokers (30.6%) and 55.6% had allergy rhinitis. Thirty six percent had controlled asthma vs. 64% were uncontrolled. The mean of the total Reflux Symptom index was significantly higher in patients compared to controls (12.03±8.3 vs. 6.64 ± 6.08, p value<0.05). In the asthmatic group, 15 subjects had a positive Reflux Symptom Index compared to only 4 in the control group (p value 0.003). There was a significant difference in the prevalence and means of four laryngopharyngeal symptoms in patients vs. controls.
CONCLUSION: Laryngopharyngeal reflux disease is more prevalent and more severe in patients with asthma vs. controls.
 

Clin Respir J. 2014 Jul 3. doi: 10.1111/crj.12179. [Epub ahead of print]