哮喘联盟

   摘要
   目的：越来越多的证据表明维生素D缺乏与哮喘急性发作的严重程度相关。本研究旨在评估成人维生素D缺乏与哮喘急性发作次数和严重程度的相关性。
   方法：回顾性分析了来自新墨西哥大学成人哮喘门92例正在接受治疗的哮喘患者。分析轻-重度持续性哮喘患者血清25-羟化维生素D3水平。采用多因素模型，评估血清维生素D水平与超过5年跨度从中度-重度的哮喘急性发作几率的关联性。
   结果：本研究证明了维生素D缺乏与哮喘急性发作总次数的下降 (发生比率 [IRR]: 0.61, 95% 置信区间 [CI]: 0.44-0.84, p = 0.002)、重度哮喘急性发作总次数下降(IRR: 0.41, 95% CI: 0.24-0.72, p = 0.002)和急诊室就诊量下降(IRR: 0.42, 95% CI:0.20-0.88, p = 0.023)显著相关。
   结论：成人维生素D缺乏可能与重度哮喘急性发作风险相关。
 

（林江涛 审校）
J Asthma. 2014 Jun 13:1-0. [Epub ahead of print]


 

Vitamin D Deficiency and Adult Asthma Exacerbations.
 

Salas NM1, Luo L, Harkins MS.
 

ABSTRACT
OBJECTIVES: There is growing evidence indicating a connection between vitamin D deficiency and the severity of asthma exacerbations. This study seeks to assess the relationship between vitamin D deficiency and the number and severity of asthma exacerbation in adults.
METHODS: A retrospective analysis was conducted of 92 patients being treated for asthma at the University of New Mexico Adult Asthma Clinic. Serum 25-hydroxyvitamin D3 levels were analyzed in adults with mild to severe persistent asthma. Using multi-variant modeling, the relationship was examined between serum vitamin D levels and the odds of asthma exacerbations ranging in severity from moderate to severe over the span of 5 years.
RESULTS: This study demonstrates that vitamin D sufficiency was significantly associated with a decreased total number of asthma exacerbations (incidence rate ratio [IRR]: 0.61, 95% confidence interval [CI]: 0.44-0.84, p = 0.002), decreased total severe asthma exacerbations (IRR: 0.41, 95% CI: 0.24-0.72, p = 0.002) and decreased emergency room visits (IRR: 0.42, 95% CI:0.20-0.88, p = 0.023).
CONCLUSION:Vitamin D deficiency may be linked to the risk of severe asthma exacerbations in adults.
 

J Asthma. 2014 Jun 13:1-0. [Epub ahead of print]