一项关于Text2Quit（一项戒烟短信程序）的随机对照试验
2014/08/11
摘要
背景：移动电话上的短信程序在帮助人们戒烟方面已经初见成效。Text2Quit是一项自动、个性化、互动的移动健康程序，它通过发送短信的形式提供建议和支持，并提醒人们戒烟。
目的：通过美国进行的随机对照试验，评估Text2Quit对生化确定的重复点戒烟率的影响。
方法：在网络上招募503位受试者，随机给予Text2Quit或自助材料。在2011年到2013年间，受试者分别在基线和入组后1、3、6个月进行戒烟状态评估。随访6个月时，收集报告过去7天未吸烟受试者的唾液。采用意向治疗分析法，且随访丢失的受试者归为吸烟者。所有分析在2013年完成。
结果：干预组通过生化检测确定的重复点戒烟率更高，为11.1%，对照组仅为5.0% (相对风险=2.22, 95% 可信区间=1.16, 4.26, P<0.05)。相似的，自我报告的重复点戒烟率在干预组(19.9%)也高于对照组(10.0%) (P<0.01)。尽管结果提示对干预对非白种人的效果大于白种人，但人口统计亚组之间疗效无显著差异。
结论：这些结果为Text2Quit程序的相对有效性提供了初期支持。
（刘国梁 审校）
Am J PrevMed.2014Jun5.pii:S0749-3797(14)00177-9.doi:10.1016/j.amepre.2014.04.010. [Epub ahead of print]
A Randomized Trial of Text2Quit: A Text Messaging Program for Smoking Cessation.
Abroms LC1, Boal AL2, Simmens SJ2, Mendel JA2, Windsor RA2.
ABSTRACT
BACKGROUND: Text messaging programs on mobile phones have shown some promise in helping people quit smoking. Text2Quit is an automated, personalized, interactive mobile health program that sends text messages to offer advice, support, and reminders about quitting smoking.
PURPOSE: To evaluate the effect of Text2Quit on biochemically confirmed repeated point prevalence abstinence in the context of an RCT conducted in the U.S.
METHODS: Participants (n=503) were recruited on the Internet and randomized to receive Text2Quit or self-help material. Between 2011 and 2013, participants were surveyed at baseline and at 1, 3, and 6 months post-enrollment to assess smoking status. Saliva was collected from participants who reported not smoking in the past 7 days at the 6-month follow-up. An intent to treat analysis was used, and those lost to follow-up were categorized as smokers. All analyses were completed in 2013.
RESULTS: Biochemically confirmed repeated point prevalence abstinence favored the intervention group, with 11.1% abstinent compared to 5.0% of the control group (relative risk=2.22, 95% CI=1.16, 4.26, p<0.05). Similarly, self-reported repeated point prevalence abstinence was higher in the intervention group (19.9%) than in the control group (10.0%) (p<0.01). Effects were found to be uniform across the analyzed demographic subgroups, although suggestive of a larger effect for non-whites than whites.
CONCLUSIONS: These results provide initial support for the relative efficacy of the Text2Quit program.
Am J PrevMed.2014Jun5.pii:S0749-3797(14)00177-9.doi:10.1016/j.amepre.2014.04.010. [Epub ahead of print]
