哮喘联盟

   摘要
   背景：成人和儿童暴露于空气传播的真菌与哮喘急性发作相关，导致门诊病人、急诊和住院率的增加。对这些空气传播真菌的超敏反应可能是在哮喘急性发作和进程中一个重要的初始诱发因素。
   目的：本研究旨在确定成人哮喘急性发作风险与真菌类型和芽孢浓度的相关性。
   方法：本横断面研究从2008年5月到2009年8月在巴基斯坦卡拉奇市阿迦汗大学医院进行。因哮喘急性发作入院的所有成人患者(年龄≥16岁)，知情同意后纳入本研究。对每一例患者进行家庭调查，旨在评估他们的环境特点。在纳入研究的一周内，从患者家中获取室内空气样本，旨在确定真菌类型和芽孢浓度。
   结果：研究期间，共纳入391例哮喘急性发作患者。受试者的平均年龄为46岁(标准差，±18岁)，其中247例(63.2%)是女性。在两个连续的夏天中发现较高的曲霉菌属浓度与较高的哮喘纳入趋势相关。空气样本中共发现19种真菌类型。曲霉菌属是导致哮喘急性发作最常见的独立真菌。
   结论：本研究表明较高的室内曲霉菌属浓度与成人哮喘急性发作相关。
 

（林江涛 审校）
Asia Pac Allergy. 2014 Apr;4(2):91-8. doi: 10.5415/apallergy.2014.4.2.91. Epub 2014 Apr 29.

 

Association of airborne Aspergillus with asthma exacerbation in Southern Pakistan.
 

Zubairi AB1, Azam I2, Awan S1, Zafar A3, Imam AA1.
 

ABSTRACT
BACKGROUND: Exposure to airborne fungi has been related with exacerbation of asthma in adults and children leading to increased outpatient, emergency room visits, and hospitalizations. Hypersensitivity to these airborne fungi may be an important initial predisposing factor in the development and exacerbation of asthma.
OBJECTIVE: This study was conducted to determine an association between fungal types and spore concentrations with the risk of asthma exacerbation in adults.
METHODS: This cross-sectional study was conducted from May 2008 to August 2009 at the Aga Khan University Hospital Karachi, Pakistan. All adult (age≥16 years) patients presenting to the hospital with acute asthma exacerbation were enrolled after informed consent. A home survey was conducted for each patient to assess their environmental characteristics. Indoor air samples were also obtained from the patient's home to determine the type and spore concentration of fungi within the week of their enrollment in the study.
RESULTS: Three hundred and ninety-one patients with an acute asthma exacerbation were enrolled during the study period. The mean age of participants was 46 years (standard deviation, ±18 years) and 247 (63.2%) were females. A trend of higher asthma enrollment associated with higher Aspergillus concentrations was found in two consecutive summers. A total of nineteen types of fungi were found in air samples. Aspergillus spp. was the most frequently isolated fungus with acute asthma exacerbation.
CONCLUSION: An association of higher concentration of indoor Aspergillus spp. with asthma exacerbation in adults was observed in this study.
 

Asia Pac Allergy. 2014 Apr;4(2):91-8. doi: 10.5415/apallergy.2014.4.2.91. Epub 2014 Apr 29.