哮喘联盟

   摘要
   背景和目的：室内空气污染能否作为中年哮喘和呼吸道症状的危险因素尚不清楚。我们旨在研究室内空气污染源和中年哮喘基因表型、哮喘相关性呼吸道症状之间的关系。
   方法：纳入5729例参加2004年塔斯马尼亚人纵向健康研究且完成呼吸道和居住环境调查问卷的受试者。评估室内空气污染源和哮喘基因表型、哮喘相关呼吸道症状之间的关系。
   结果：室内新霉斑与当前哮喘(优势比(OR) 1.26；95%CI 1.06-1.50)、喘息(OR 1.34；1.17-1.54) 和夜间胸闷(OR 1.30；1.12-1.51)有关。按照特应性和性别进行分层，新的霉斑与当前男性非过敏性哮喘有关（OR 3.73；1.29-10.80）。更多被霉斑污染的房间与哮喘、喘息和夜间胸闷显著相关。室内环境烟草烟雾与医生诊断的哮喘（OR 1.25；1.02-1.53）、喘息（OR 1.69；1.41-2.03）、夜间胸闷（OR 1.54; 1.26-1.88）、当前非吸烟者哮喘（OR 2.09；95%：1.30-3.35）和当前男性哮喘（OR 1.74；95%: 1.25-2.42)有关。使用加热器和逆循环式空调与医生诊断的哮喘成负相关（OR 0.84；0.70-1.00）。使用电器或燃气灶与哮喘基因表型或哮喘相关性呼吸道症状有关。
   结论：中年人减少室内霉斑暴露和环境烟草烟雾暴露可能降低哮喘和哮喘相关性呼吸道症状。
 

（苏楠 审校）
Respirology. 2014 Feb 12. doi: 10.1111/resp.12245. [Epub ahead of print]


 

Domestic airborne pollutants and asthma and respiratory symptoms in middle age.
 

Mészáros D, Burgess J, Walters EH, Johns D, Markos J, Giles G, Hopper J, Abramson M, Dharmage SC, Matheson M.
 

Abstract
BACKGROUND AND OBJECTIVE: The role of indoor air pollution as a risk factor for asthma and respiratory symptoms in middle age is unclear. We investigated associations between indoor air pollution sources and (i) asthma phenotypes and (ii) asthma-related respiratory symptoms in middle-aged adults.
METHODS: Subjects (n = 5729) who participated in the 2004 survey of the Tasmanian Longitudinal Health Study completed respiratory and home environment questionnaires. Associations between indoor air pollution sources, and asthma phenotypes and asthma-related respiratory symptoms were estimated.
RESULTS: Recent mould in the home was associated with current asthma (odds ratio (OR) 1.26; 95% confidence interval 1.06-1.50), wheeze (OR 1.34; 1.17-1.54) and nocturnal chest tightness (OR 1.30; 1.12-1.51). Stratified by atopy and gender, recent mould was associated with current non-atopic asthma only in males (OR 3.73; 1.29-10.80). More rooms affected by mould were associated with significant trends for current asthma, wheeze and nocturnal chest tightness. Home environmental tobacco smoke was associated with doctor-diagnosed asthma (OR 1.25; 1.02-1.53), wheeze (OR 1.69; 1.41-2.03), nocturnal chest tightness (OR 1.54; 1.26-1.88), with current asthma only in non-smokers (OR 2.09; 95%: 1.30-3.35) and with current asthma only in males (OR 1.74; 95%: 1.25-2.42). Among heating appliances, reverse cycle air conditioning was negatively associated with doctor-diagnosed asthma (OR 0.84; 0.70-1.00). Neither electric nor gas stove use was associated with either asthma phenotype or with asthma-related respiratory symptoms.
CONCLUSIONS: In middle age, reducing home exposure to mould and environmental tobacco smoke might reduce asthma and asthma-related respiratory symptoms.
 

Respirology. 2014 Feb 12. doi: 10.1111/resp.12245. [Epub ahead of print]