哮喘联盟

   摘要
   背景：慢性咳嗽是一种常见的、令人烦恼的症状。胃-食管反流是引起慢性咳嗽的常见原因，但是咳嗽症候并不局限于典型的消化道症状。消化不良症状已证明对饮食调整和体重减轻有应答。我们假设体重减轻可能是降低肥胖患者反流性咳嗽的一种有效的非药物治疗方法。
   方法：咳嗽受试者来自赫尔咳嗽诊所。他们被随机分到两个平行组：一组接受传统的饮食调整，另一组以能量处方（EP）的形式进行体重减轻治疗。咳嗽症状采用莱塞斯特咳嗽量表（LCQ）进行评分，在研究的开始和结束时检测饮食摄入量。
   结果：33位患者纳入研究，共有20位患者完成了研究。受试者平均体重减轻为3.1kg（p<0.001），LCQ评分显著提高（平均提高3.1分），比临床重要评分高1.3分。此外，次要结果显示基线高热量（r = -0.24; p < 0.001）和脂肪摄入量（r = -0.36; p = 0.001）与LCQ得分显著相关。
   结论：高热量和脂肪摄入量与咳嗽评分显著相关。不考虑饮食因素，体重减轻可显著减少咳嗽症状。建议患者通过减少脂肪和热量的摄入以减轻体重，这可能是改善咳嗽这种棘手症状的一种简单方法。
   试验注册：本研究得到当地研究伦理委员会的批准（南汉伯当地研究伦理委员会；REC04/Q1105/62）。本研究由赫尔和东约克郡医院国家医疗服务基金会，临床管理理事会，研究和发展部注册（参考号R0086）。

 

（刘国梁 审校）
Cough. 2013 Dec 31;9(1):27. doi: 10.1186/1745-9974-9-27.
 

Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire.
 

Smith JE, Morjaria JB, Morice AH.
 

Abstract
BACKGROUND: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown to respond to dietary modifications and weight loss. We hypothesised that weight reduction maybe a useful non-pharmacological strategy in reducing reflux cough in the obese.
METHODS: Subjects with cough were recruited from Hull Cough Clinic. They were randomised to one of two open parallel groups; one receiving the traditional dietary modifications and the other weight reduction advice in the form of an Energy Prescription (EP). Cough symptoms, using the Leicester cough questionnaire (LCQ) and dietary intake were measured at the start and end of the study.
RESULTS: Thirty-three patients were recruited and 20 patients completed the study. Mean weight loss was 3.1 kg (p < 0.001) and reported an improvement in the LCQ (mean improvement 3.1); which is greater than the clinically significant score of 1.3. . Moreover, secondary outcomes showed a significant association between baseline high calorie (r = -0.24; p < 0.001) and fat intake (r = -0.36; p = 0.001), and LCQ scores.
CONCLUSION: A high calorie and fat intake is strongly correlated with cough score. Irrespective of diet, weight loss is associated with a reduction in cough symptoms. Asking patients to lose weight by reducing fat and calorie intake may be a simple strategy to ameliorate this intractable condition.
TRIAL REGISTRATION: The study was approved by the local research ethics committee (South Humber Local Research Ethics Committee; REC04/Q1105/62). The study was registered with the Research and Development Department, Clinical Governance Directorate, Hull and East Yorkshire Hospitals NHS Trust (reference number R0086).
 

Cough. 2013 Dec 31;9(1):27. doi: 10.1186/1745-9974-9-27.