哮喘联盟

   摘要
   背景：慢性咳嗽的机制不明。许多活性氧对可导致咳嗽的气道感官C-纤维有影响。许多慢性肺病的特点是咳嗽和氧化应激。在哮喘中，咳嗽严重性已证明与呼吸道氧化应激有关。本研究旨在调查在无慢性肺病人群，呼吸道氧化应激是否与慢性咳嗽有关。
   方法：研究取得了43例非吸烟慢性咳嗽患者和15例健康者的呼出气浓缩样本。排除标准包括医生诊断的任何肺部疾病和肺部X射线检查的任何异常。研究检测了8-异前列烷浓度。此外，患者完成了莱斯特咳嗽问卷、高渗生理盐水激发试验、呼吸量测定、步行最大流量监控、NO测量和呼吸道组胺激发。对于经过12周吸入布地奈德（800 ug/day）治疗的亚组患者，再次进行以上检测。
   结果：咳嗽患者中8-异前列烷浓度高于健康对照(24.6 ± 1.2 pg/ml vs. 10.1 ± 1.7 pg/ml, p = 0.045)。8-异前列烷浓度与莱斯特咳嗽问卷总分相关(p = 0.044)，但与生理盐水激发的咳嗽严重性和其它检测结果无关。布地奈德治疗对8-异前列烷浓度无影响。
   结论：慢性咳嗽看起来与慢性咳嗽患者呼吸道氧化应激有关，而非慢性肺病患者。本发现可能有助于新型止咳药的研发。

 

（刘国梁 审校）
Cough. 2013 Dec 2;9(1):26.

Airway oxidative stress in chronic cough.

Koskela HO, Purokivi MK.

ABSTRACT
BACKGROUND: The mechanisms of chronic cough are unclear. Many reactive oxygen species affect airway sensory C-fibres which are capable to induce cough. Several chronic lung diseases are characterised by cough and oxidative stress. In asthma, an association between the cough severity and airway oxidative stress has been demonstrated. The present study was conducted to investigate whether airway oxidative stress is associated with chronic cough in subjects without chronic lung diseases.
METHODS: Exhaled breath condensate samples were obtained in 43 non-smoking patients with chronic cough and 15 healthy subjects. Exclusion criteria included a doctor's diagnosis of any lung disorders and any abnormality in lung x-ray. The concentration of 8-isoprostane was measured. In addition, the patients filled in Leicester Cough Questionnaire and underwent hypertonic saline cough provocation test, spirometry, ambulatory peak flow monitoring, nitric oxide measurement, and histamine airway challenge. In a subgroup of patients the measurements were repeated during 12 weeks' treatment with inhaled budesonide, 800 ug/day.
RESULTS: The 8-isoprostane concentrations were higher in the cough patients than in the healthy subjects (24.6 ± 1.2 pg/ml vs. 10.1 ± 1.7 pg/ml, p = 0.045). The 8-isoprostane concentration was associated with the Leicester Cough Questionnaire total score (p = 0.044) but not with the cough sensitivity to saline or other tests. Budesonide treatment did not affect the 8-isoprostane concentrations.
CONCLUSIONS: Chronic cough seems to be associated with airway oxidative stress in subjects with chronic cough but without chronic lung diseases. This finding may help to develop novel antitussive drugs.
 

Cough. 2013 Dec 2;9(1):26.