哮喘联盟

   摘要
   背景：目前关于哮喘患者死亡原因的资料是有限的。本研究目的旨在确定哮喘住院患者的死亡原因，并与COPD患者和非呼吸系统疾病个体的死因进行比较，尤其是既往有心血管疾病的人群。
   方法：采用回顾性病例对照研究，对在2008年1月、4月、7月和10月期间西班牙13个中心因任何原因住院的所有住院患者的死亡原因进行分析。查阅已故患者的病例，并收集人口统计学和临床数据。
   结果:本研究共纳入2826例死亡患者(平均年龄 75 岁, 男性占56%)，其中82例(2.9%)为哮喘患者，283例(10%)为COPD患者。导致哮喘患者死亡的最常见原因为心血管疾病(29.3%)，恶性肿瘤(20.7%)和感染(14.6%)；COPD患者死亡最常见原因为恶性肿瘤(26.5%)，急性呼吸衰竭(25.8%)和心血管疾病(21.6%)。与COPD患者相比，哮喘患者由于急性呼吸衰竭和肺癌导致的死亡率显著减少。多因素logistic回归分析未能确定哮喘与心血管死亡的关联性。
   结论：心血管疾病是导致哮喘住院患者最常见死亡原因。哮喘和COPD患者的具体死亡原因是有差异的。
 

（林江涛 审校）
BMC Pulm Med. 2013 Dec 10;13(1):73. [Epub ahead of print]

 

"Causes of death in asthma, COPD and non-respiratory hospitalized patients: a multicentric study"
 

Soto-Campos JG, Plaza V, Soriano JB, Cabrera-López C, Almonacid-Sánchez C, Vazquezoliva RM, Serrano J, Ballaz-Quincoces A, Galo AP, Santos V.
 

ABSTRACT
BACKGROUND: There is limited information on the causes of death in asthma patients. Objectives: To determine the causes of death in hospitalized asthmatic patients and to compare with those observed in COPD patients and non-respiratory individuals, with a particular interest in associations with previous cardiovascular disease.
METHODS: Retrospective case-control study which analyzed the deaths of all hospitalized patients admitted for any reason during January, April, July and October of 2008 in 13 Spanish centers. Medical records of deceased patients were reviewed, and demographic and clinical data were collected.
RESULTS: A total of 2,826 deaths (mean age 75 years, 56% men) were included in the analysis, of which 82 (2.9%) were of patients with asthma and 283 (10%) with COPD.The most common causes of death in asthma patients were cardiovascular diseases (29.3%), malignancies (20.7%) and infections (14.6%); in COPD patients they were malignancies (26.5%), acute respiratory failure (25.8%) and cardiovascular diseases (21.6%). Asthma, compared to COPD patients, died significantly less frequently from acute respiratory failure and lung cancer. A multivariate logistic regression analysis failed to associate asthma with cardiovascular deaths.
CONCLUSIONS: Cardiovascular disease is the most frequent cause of death among hospitalized asthma patients. The specific causes of death differ between asthma and COPD patients.
 

BMC Pulm Med. 2013 Dec 10;13(1):73. [Epub ahead of print]