哮喘联盟

   摘要
   背景：为了理解戒烟疲劳的动态过程（如，努力戒烟产生的疲劳），包括其平均趋势、对复发的影响、与吸烟欲望和负面情绪的时间变化关系以及性别差异和治疗组差异。
   方法：随机、安慰剂对照临床试验。参加者分别接受安慰剂、单药治疗（安非他酮SR、尼古丁贴片、尼古丁锭剂）或联合药物治疗（安非他酮SR+尼古丁锭剂、尼古丁贴片+尼古丁锭剂）。数据来自于1504例积极戒烟的每日吸烟者。参加者完成基线评估和戒烟后2周生态瞬时评估。
   结果：戒烟疲劳可降低戒烟6个月后不吸烟可能性（OR=0.97, 95% CI (0.95, 0.99)），并与吸烟欲望和负面情绪正相关。控制这两个因素后，平均戒烟疲劳随时间而增加。相比男人，女人疲劳感更强（t=-10.69, p<0.0001），疲劳和吸烟欲望的关联性也更强（t=-8.80, p<0.0001）。疲劳和负面情绪的关联性在男人中明显更强（t=5.73, p<0.0001）。联合药物治疗（t=-13.4, p<0.0001）和单药治疗（t=-6.2, p<0.0001）可显著降低戒烟疲劳。
   结论：戒烟疲劳与吸烟欲望、负面情绪和戒烟结果紧密相关。妇女报告的戒烟疲劳大于男人。目前治疗可降低疲劳，并减弱其与吸烟欲望和负面情绪的关系。
 

（刘国梁 审校）
Drug Alcohol Depend. 2013 Dec1;133(2):548-55.doi:10.1016/j.drugalcdep.2013.07.025. Epub 2013 Aug 2.

 

Understanding the role of cessation fatigue in the smoking cessation process.
 

Liu X, Li R, Lanza ST, Vasilenko SA, Piper M.
 

Abstract
BACKGROUND: To understand the dynamic process of cessation fatigue (i.e., the tiredness of trying to quit smoking) with respect to its average trend, effect on relapse, time-varying relations with craving and negative affect, and differences among genders and treatment groups.
METHOD: Randomized placebo-controlled clinical trial. Participants received either placebo, monotherapy (bupropion SR, nicotine patch, nicotine lozenge), or combined pharmacotherapy (bupropion SR+nicotine lozenge, nicotine patch+nicotine lozenge). Data were collected from 1504 daily smokers who were motivated to quit smoking. The participants completed baseline assessments and ecological momentary assessments for 2 weeks post-quit.
RESULTS: Cessation fatigue reduced the likelihood of 6-month post-quit abstinence (OR=0.97, 95% CI (0.95, 0.99)), and was positively associated with craving and negative affect. After controlling for these two factors, average cessation fatigue increased over time. Compared to men, women experienced greater fatigue (t=-10.69, p<0.0001) and a stronger relation between fatigue and craving (t=-8.80, p<0.0001). The relationship between fatigue and negative affect was significantly stronger in men (t=5.73, p<0.0001). Cessation fatigue was significantly reduced by combined pharmacotherapy (t=-13.4, p<0.0001), as well as monotherapy (t=-6.2, p<0.0001).
CONCLUSIONS: Cessation fatigue was closely related to craving, negative affect, and cessation outcomes. Women reported greater cessation fatigue than men. Current treatments appeared to reduce fatigue and weaken its relations with craving and negative affect.
 

Drug Alcohol Depend. 2013 Dec1;133(2):548-55.doi:10.1016/j.drugalcdep.2013.07.025. Epub 2013 Aug 2.