哮喘联盟

   摘要
   介绍：戒烟后体重增加是一个常被提及的戒烟障碍。一些证据提示尼古丁替换疗法可能通过降低能量摄入，抑制戒烟后体重增加。本项目中将绝经后妇女随机分为接受12周21mg尼古丁或安慰剂贴片组，旨在此样本中评估戒烟期间能量摄入和体重的变化。
   方法：本双盲、随机、安慰剂对照研究纳入吸烟量≥10根/天的绝经后妇女。在以下三个时间点评估总能量摄入（通过四天饮食记录）、身体质量指数（BMI；kg/m(2)）、香烟数/天和吸烟状态（自己报告并通过吸入一氧化碳验证）：开始戒烟前2周、开始戒烟后12周、戒烟治疗后12个月。
   结果：参与者（n=119）平均年龄55.8±6.7岁，平均基础BMI27.0±5.2，平均吸烟量为21.1±8.6根/天。12周时，尼古丁贴片组平均热量摄入增加了146.4±547.7千卡/天，而安慰剂组热量摄入降低了175.3±463.2千卡/天（f值=10.1, p值=0.002）。尽管热量摄入不同，两组体重保持相似。
   结论：本研究结果表明尼古丁贴片可能增加治疗中能量摄入，不能预防绝经后吸烟妇女戒烟后体重增加。还需更多研究来确证这些发现并评估不同形式的尼古丁替换疗法是否对绝经后吸烟妇女热量摄入和戒烟后体重增加有影响。
 

（刘国梁 审校）
Eat Behav. 2013 Dec;14(4):420-3. doi: 10.1016/j.eatbeh.2013.07.007. Epub 2013 Jul 21.

 

Effect of nicotine patch on energy intake and weight gain in postmenopausal women during smoking cessation.
 

Allen AM, Kleppinger A, Lando H, Oncken C.
 

Abstract
INTRODUCTION: Post-cessation weight gain is a commonly cited barrier to smoking cessation. Some evidence suggests that nicotine replacement therapy may limit post-cessation weight gain by reducing energy intake. This project aims to assess differential changes in energy intake and body weight during smoking cessation in a sample of postmenopausal women randomized to receive 21mg nicotine or placebo patch for 12weeks.
METHODS: Postmenopausal women who smoked ≥10cigarettes/day were enrolled in this double-blind randomized placebo-controlled study. Total energy intake (via four-day food diaries), body mass index (BMI; kg/m(2)), cigarettes/day and smoking status (self-report verified by exhaled carbon monoxide) were assessed at three time points: 2weeks prior to quit date,12weeks after quit date, and 12months after smoking cessation treatment.
RESULTS: Participants (n=119) were, on average, 55.8±6.7years old with a baseline BMI of 27.0±5.2 and average cigarette/day was 21.1±8.6. At Week 12, participants randomized to nicotine patch increased their mean caloric intake by 146.4±547.7kcal/day whereas those on placebo patch decreased their caloric intake by 175.3±463.2 (f-value=10.1, p-value=0.002). Despite the differences in caloric intake, body weight remained similar between groups.
CONCLUSIONS: The results of this study indicate that nicotine patch may increase energy intake during treatment, and does not prevent post-cessation weight gain in postmenopausal smokers. Additional research is needed to replicate these findings and assess whether different forms of nicotine replacement therapy influence caloric intake and post-cessation weight gain in postmenopausal smokers.
 

Eat Behav. 2013 Dec;14(4):420-3. doi: 10.1016/j.eatbeh.2013.07.007. Epub 2013 Jul 21.