哮喘联盟

   摘要
   目的：评估异丙嗪和右美沙芬治疗1～12岁上呼吸道感染（URI）儿童，是否可降低夜间咳嗽、提高睡眠质量。
   方法：本随机、双盲、安慰剂对照试验在德里Lok Nayak医院儿科门诊部开展。随机分为异丙嗪、右美沙芬和安慰剂组后，在入组前晚上、第3次治疗后对120例URI儿童夜间咳嗽严重性（儿童）、咳嗽后呕吐（儿童）和睡眠质量（儿童和家长）进行家长评估，并采用一个内部验证的自主准备顺序量表进行测量。
   结果：3天后全体队列的所有研究数据均有所改善。但是，相比安慰剂组，异丙嗪组和右美沙芬组中无单个参数显示优势。右美沙芬和异丙嗪组不良反应发生率较高，但无统计学差异。
   结论：URI患者夜间咳嗽是自愈性的，右美沙芬和异丙嗪处方均未优于安慰剂。
 

（刘国梁 审校）
IndianJPediatr.2013Nov;80(11):891-5.doi:10.1007/s12098-013-1002-2.Epub2013Apr 17.

 

To Compare the Effect of Dextromethorphan, Promethazine and Placebo on Nocturnal Cough in Children Aged 1-12 y with Upper Respiratory Infections: A Randomized Controlled Trial.
 

Bhattacharya M, Joshi N, Yadav S.
 

Abstract
OBJECTIVES:To evaluate whether promethazine and dextromethorphan reduce nocturnal cough and improve sleep quality in children aged 1-12 y with upper respiratory tract infection (URI).
METHODS: This randomised double-blinded placebo-controlled trial was conducted in Pediatric outpatient department of Lok Nayak Hospital, Delhi. After randomization into promethazine, dextromethorphan and placebo groups, parental assessment of 120 children with URI for nocturnal cough severity (child), post-tussive vomiting (child) and sleep quality (child and parent) on the night before enrolment and after 3 d of assigned medication was measured using an internally validated indigenously prepared ordinal scale.
RESULTS: Entire cohort improved in all the study parameters after 3 d. However, no superior benefit was noted when individual parameters were compared in the promethazine and dextromethorphan groups with the placebo group. Adverse effects were more frequent in the dextromethorphan and promethazine groups although the difference was not statistically significant.
CONCLUSIONS: Nocturnal cough in URI is self-resolving and dextromethorphan and promethazine prescribed for the same are not superior to placebo.
 

IndianJPediatr.2013Nov;80(11):891-5.doi:10.1007/s12098-013-1002-2.Epub2013Apr 17.