哮喘联盟

   摘要
   背景：阻塞性睡眠呼吸暂停（OSA）近来被发现是慢性咳嗽的可能病因。本研究旨在比较伴或不伴OSA人群的慢性咳嗽发生率，并研究持续呼吸道加压治疗（CPAP）对缓解慢性咳嗽的影响。
   方法：研究回顾性入组2012.1-2012.6期间睡眠实验室的相关患者。对临床数据、治疗疗程和慢性咳嗽缓解情况进行分析。特别对胃食管反流（GERD）、上呼吸道咳嗽症状、哮喘、呼吸暂停-呼吸功能不全指数和CPAP治疗对慢性咳嗽的影响进行评估。
   结果：共回顾了131例患者。OSA组慢性咳嗽发生率显著高于非OSA组（39/99 (39.4%) vs. 4/32 (12.5%)，p = 0.005）。单变量分析中GERD和呼吸暂停-呼吸功能不全指数与慢性咳嗽显著相关。多元logistic回归分析后，只有GERD是慢性咳嗽的独立因素。此外，相比未接受CPAP治疗，CPAP治疗的OSA组患者慢性咳嗽缓解情况更显著。（2/21 (9.5%) vs.12/18 (66.7%)，p = 0.010）。
   结论：OSA患者慢性咳嗽发生率显著增加。此外，CPAP治疗可显著改善慢性咳嗽。因此，OSA可能是慢性咳嗽的促进因素。
 

（刘国梁 审校）
Cough. 2013 Nov 5;9(1):24. [Epub ahead of print]

 

Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice.
 

Wang TY, Lo YL, Liu WT, Lin SM, Lin TY, Kuo CH, Chung FT, Chou PC, Chang PJ, Ni YL, Ho SC, Lin HC, Wang CH, Yu CT, Kuo HP.
 

Abstract
BACKGROUND: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough.
METHODS: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Clinical data, treatment course and resolution of chronic cough were analysed. Specifically, gastro-oesophageal reflux (GERD), upper airway cough syndrome, asthma, apnoea-hypopnoea index and the impact of CPAP treatment on chronic cough were assessed.
RESULTS: A total of 131 patients were reviewed. The incidence of chronic cough in the OSA group was significantly higher than the non-OSA group (39/99 (39.4%) vs. 4/32 (12.5%), p = 0.005). Both GERD and apnoea-hypopnoea index were significantly associated with chronic cough in univariate analysis. After multivariate logistic regression, GERD was the only independent factor for chronic cough. Moreover, the resolution of chronic cough was more significant in the OSA patients with CPAP treatment compared with those not receiving CPAP treatment (12/18 (66.7%) vs. 2/21 (9.5%), p = 0.010).
CONCLUSION: The incidence of chronic cough was significantly higher in the OSA patients. In addition, CPAP treatment significantly improved chronic cough. Therefore, OSA may be a contributory factor to chronic cough.
 

Cough. 2013 Nov 5;9(1):24. [Epub ahead of print]