哮喘联盟

   摘要
   目的：Pelican仪器是一个荷兰在线的、自我操作的生活质量仪器，用于儿童哮喘，包括科研应用和临床应用。本研究旨在评估Pelican仪器的心理测验属性。
   方法：在两个哮喘人群和健康儿童中进行一项队列研究。对一个哮喘人群进行3次评估：开始时、4周和8周时。对另外一个哮喘人群和健康儿童只进行一次评估。所有儿童均为6～12岁。儿童完成了Pelican仪器使用、儿科哮喘生活质量问卷、体温计测量以及儿童哮喘控制测试。检测了肺功能和呼出一氧化氮分数。父母完成了功能状态II、哮喘控制问卷、儿童哮喘控制测试问卷和症状日记。我们评估了Pelican仪器的可解释性、结构效度、内部一致性、信度以及架构和区分效度。
   结果：85例哮喘患儿（平均年龄8.5岁）和49例健康儿童（平均年龄8.4岁）参加了本研究。因素分析后，Pelican仪器有5个区域，21个指标。内部一致性为0.89，区域信度显示Cronbach's α's系数为0.64-0.78，指标-等级相关性为0.61-0.81。再测信度ICC为0.88 (CI 0.79-0.93)。与其它相关哮喘结局如PAQLQ有明显中度相关性(r = -0.59, p < 0.01)证明其有结构效度。结果发现其具备对可控和不可控哮喘(t = 3.20, p < 0.01, Δ = 0.64)以及哮喘和健康人群(t = 3.20, p < 0.01, Δ = 0.64)的区分能力。
   结论：Pelican仪器的心理测验属性在荷兰6～12岁的哮喘患儿中是可接受的。
 

（苏楠 审校）
Qual Life Res. 2013 Oct 1. [Epub ahead of print]
 

Validity, reliability and discriminative capacity of an electronic quality of life instrument (Pelican) for childhood asthma in the Netherlands.
 

van Bragt S, van den Bemt L, Thoonen B, Jacobs J, Merkus P, Schermer T.
 

ABSTRACT
PURPOSE: To assess psychometric properties of the Pelican instrument, an online Dutch self-administered Quality of Life instrument for childhood asthma for scientific and clinical use.
METHODS: A cohort study was done in two asthma populations and healthy children. One asthma population had assessment at start, 4 and 8 weeks. The other asthma population and healthy children had one assessment. All children were aged 6-12 years. Children completed the Pelican instrument, Paediatric Asthma Quality of Life Questionnaire, feeling thermometer and Childhood Asthma Control Test. Lung function and fraction exhaled nitric oxide were measured. Parents completed Functional Status II, Asthma Control Questionnaire, Childhood Asthma Control Test questionnaires and symptom diaries. We assessed interpretability, structural validity, internal consistency, reliability, construct and discriminative validity of the Pelican instrument.
RESULTS: Eighty-five asthmatic (mean age 8.5 years) and 49 healthy children (mean age 8.4 years) participated. The Pelican instrument has 5 domains with 21 items after factor analysis. Internal consistency was 0.89 (CI 0.85-0.92), domain reliability showed Cronbach's α's from 0.64 to 0.76 and item-to-scale correlations from 0.61 to 0.81. Test-retest reliability was confirmed ICC = 0.88 (CI 0.79-0.93). Construct validity was demonstrated by significant moderate correlations with other relevant asthma outcomes like PAQLQ (r = -0.59, p < 0.01). Discriminative capacity between controlled or uncontrolled asthma (t = 3.20, p < 0.01, Δ = 0.64) and asthma versus healthy subjects (t = 6.31, p < 0.01, Δ = 0.94) was found.
CONCLUSIONS: The psychometric properties of the Pelican instrument were acceptable in Dutch paediatric asthma patients between 6 and 12 years old.
 

Qual Life Res. 2013 Oct 1. [Epub ahead of print]