哮喘联盟

   摘要
   目的：哮喘可增加气道相关的感染风险。而关于其是否也增加非气道相关严重感染，如大肠杆菌血流感染（BSI），目前还知之甚少。我们评估了哮喘是否与社区获得性大肠杆菌BSI风险相关。
   设计：本研究是一项以人群为基础的回顾性病例对照研究。
   背景：这项以人群为基础的研究在明尼苏达州奥姆斯特德县进行。
   参加者：本研究纳入1998-2007年间259例来自奥姆斯特德县的所有社区获得性大肠杆菌BSI合格患者，并纳入259名出生日期、性别、居住地匹配的对照者。
   首要、次要研究终点：只有主要诊断为社区获得性大肠杆菌BSI的患者可入组本研究。采用预设标准以确定患者是否为哮喘暴露状态。采用条件logistic回归法计算哮喘与社区获得性大肠杆菌BSI风险关联度的校正OR和95%CI。
   结果：在259例合格患者中，179(69%)例为妇女，平均年龄为61±22岁。259例患者中，37 (14%)例既往有哮喘史；而在259例对照者中，16 (6%)例既往有哮喘史(校正OR 2.74; 95% CI 1.11-6.76; p=0.029)。对于社区获得性大肠杆菌BSI，哮喘的人群归因危险度为9%。尽管没有统计学差异，食物过敏史与社区获得性大肠杆菌BSI风险增加仍有边缘联系(6% vs 2%; 校正OR 3.51; 95% CI 0.94-13.11; p=0.062)
   结论：基于目前这个以人群为基础的病例对照研究结果，哮喘史可能与社区获得性大肠杆菌BSI风险相关。哮喘对微生物感染风险的影响可能超出了呼吸道。
 

（苏楠 审校）
BMJ Open. 2013 Oct 3;3(10):e003857. doi: 10.1136/bmjopen-2013-003857.


 

Asthma and risk of non-respiratory tract infection: a population-based case-control study.
 

Bang DW, Yang HJ, Ryoo E, Al-Hasan MN, Lahr B, Baddour LM, Yawn BP, Juhn YJ.
 

ABSTRACT
OBJECTIVES: Asthmatics have increased risks of airway-related infections. Little is known about whether this is true for non-airway-related serious infections such as Escherichia coli bloodstream infection (BSI). We assessed whether asthma is associated with a risk of developing community-acquired E coli BSI.
DESIGN: The study was designed as a population-based retrospective case-control study.
SETTING: This population-based study was conducted in Olmsted County, Minnesota.
PARTICIPANTS: The study included 259 all eligible community-acquired E coli BSI cases in Olmsted County, MN between 1998 and 2007 and 259 birthday-matched, gender-matched and residency-matched controls.
PRIMARY AND SECONDARY OUTCOME MEASURES: Only community-acquired E coli BSI cases as the primary outcome was included. Asthma status as an exposure was ascertained by predetermined criteria. An adjusted OR and 95% CI for the association between asthma and risk of community-acquired E coli BSI was calculated using conditional logistic regression.
RESULTS: Of 259 eligible cases, 179 (69%) were women and mean age was 61±22 years. Of the 259 cases 37 (14%) and 16 (6%) of 259 controls had a prior history of asthma (adjusted OR 2.74; 95% CI 1.11 to 6.76; p=0.029). The population attributable risk of asthma for community-acquired E coli BSI was 9%. Although not statistically significant, there was a borderline association between having a history of food allergy and increased risk of community-acquired E coli BSI (6% vs 2%; adjusted OR 3.51; 95% CI 0.94 to 13.11; p=0.062).
CONCLUSIONS: Based on the findings of the current population-based, case-control investigation, a history of asthma may be associated with risk of community-acquired E coli BSI. The impact of asthma on risk of microbial infections may go beyond airways.
 

BMJ Open. 2013 Oct 3;3(10):e003857. doi: 10.1136/bmjopen-2013-003857.