哮喘联盟

   摘要
   导致哮喘的发病机制多种多样，并受多种基因多态性和环境因素的影响。最近的呼吸道微生物学数据显示健康人和哮喘患者之间的微生物种群在数量和多样性上存在有趣差异。有力数据证明早期病毒感染，特别是人鼻病毒和呼吸道合胞体病毒，通常与慢性哮喘发展和发作有关。最近研究提示两种不相关的非典型性细菌种类，肺支原体和肺炎衣原体，存在于一大部分人群的呼吸道中，从而带来了这种持续存在的微生物可导致一部分患者发生哮喘的可能性。本综述将研究目前关于感染在慢性哮喘中的可能作用的数据，并将特别关注非典型性细菌感染。
 

（苏楠 审校）
Curr Allergy Asthma Rep. 2013 Oct 3. [Epub ahead of print]
 

Is Asthma an Infectious Disease? New Evidence.
 

Atkinson TP.
 

ABSTRACT
The pathogenetic mechanisms leading to asthma are likely to be diverse, influenced by multiple genetic polymorphisms as well as elements of the environment. Recent data on the microbiome of the airway have revealed intriguing differences between the number and diversity of microbial populations in healthy persons and asthmatics. There is convincing evidence that early viral infections, particularly with human rhinovirus and respiratory syncytial virus, are often associated with the development of chronic asthma and with exacerbations. Recent studies suggest that two unrelated types of atypical bacteria, Mycoplasma pneumoniae (Mpn) and Chlamydia pneumoniae, are present in the airways of a substantial proportion of the population, bringing up the possibility that the persistent presence of the organism may contribute to the asthmatic phenotype in a subset of patients. This review will examine the current data regarding a possible role for infection in chronic asthma with a particular focus on atypical bacterial infections.
 

Curr Allergy Asthma Rep. 2013 Oct 3. [Epub ahead of print]