哮喘联盟

   摘要
   简介：本研究旨在通过胸部HRCT评估轻度间歇性哮喘患者相比于健康对照受试者的支气管壁厚度。
   方法：本病例-对照研究共纳入了37例轻度间歇性哮喘患者(平均(标准差SD)年龄：36.7 (9.7)岁，男性占54.8%)和13例健康对照者(平均(SD)年龄：25.0(2.9)岁，男性占61.5%)。记录人口统计学数据呼吸功能试验结果、以及分段和次分段胸部HRCTs检查结果。计算所有病例支气管壁厚度与支气管管腔直径的比值(T/D)以及支气管壁面积的百分比(WA %)。
   结果：病例组与对照组的呼吸功能试验结果、以及总体和次分段T/D值相似。病例组下肺静脉(55.6(16.8) vs. 41.7(7.4); p=0.047)和隔膜上2cm(49.8(15.8) vs. 38.6(10.4); p=0.046)的次分段WA%值显著高于对照组。两组的总体和次分段T/D值和WA%值与年龄和哮喘持续时间均无显著相关性。
   结论：本研究结果显示不管哮喘的持续时间如何，轻度间歇性哮喘患者外围气道的支气管壁厚度都是增加的。这可能预示着早期给予抗炎或支气管扩张剂治疗对外围气道也是有效的。
 

（林江涛 审校）
Respir Care. 2013 Oct 8. [Epub ahead of print]


 

Evaluation of airway wall thickness via high resolution computerized tomography (HRCT) in mild intermittent asthma.
 

Asker S, Asker M, Ozbay B.
 

Abstract
INTRODUCTION: This study aims to evaluate bronchial thickness via thorax HRCT in subjects with mild intermittent asthma in comparison to healthy control subjects.
METHODS: A total of 37 outpatients (mean (standard deviation; SD) age: 36.7 (9.7) years, 54.8% males) with mild intermittent asthma and 13 healthy controls (mean (SD) age: 25.0 (2.9) years, 61.5% males) were included in this case control study. Data on demographics, respiratory function tests segmental and subsegmental thorax HRCTs were recorded. The ratio of the bronchial wall thickness to the bronchial lumen diameter (T/D) and bronchial wall area percentage (WA %) were calculated for all cases.
RESULTS:Subject and control groups were similar in terms of respiratory function tests, total and subsegmental T/D. Subsegmental WA% values at the level of inferior pulmonary vein (55.6(16.8) vs. 41.7(7.4); p=0.047) and 2 cm above the diaphragm (49.8(15.8) vs. 38.6(10.4); p=0.046) were significantly higher in subjects than controls. No significant correlation of overall and subsegmental T/D and WA% values to age in both groups and to asthma duration in subjects.
CONCLUSION:Our findings revealed increase in bronchial wall thickness in peripheral airways in subjects with mild intermittent asthma regardless of the duration of asthma. This may indicate the need to administration of anti-inflammatory or bronchodilator therapy effective on peripheral airways also in the early period.
 

Respir Care. 2013 Oct 8. [Epub ahead of print]