哮喘联盟

   摘要
   目的：评价戒烟、妊娠期和产后体重的增加和新生儿出生体重间的关系。
   方法：本研究前瞻性分析了处于单胎妊娠期的1774女性。怀孕期间吸烟状况分为不吸烟者、吸烟者和戒烟者；产后1年吸烟状况分为不吸烟者、吸烟者、重复戒烟者和持续戒烟者。通过线性回归分析来评价吸烟状况与妊娠期体重增加，产后1年体重增加以及新生儿出生体重间的关系；多因素logistic回归分析评价吸烟状况与新生儿出生体重少于孕妇年龄和性别的第10百分位之间的相关性。
   结果：比较不吸烟者、吸烟者和戒烟者妊娠16周的体重增加情况。戒烟者妊娠37周校正后的平均增加体重高于不吸烟者2.0kg(95% CI:1.5-2.6)。新生儿出生体重少于第10百分位的比率在吸烟者中为21.7%、戒烟者中为8.0%、不吸烟者中为7.4%。吸烟者中新生儿出生体重少于第10百分位的校正比值比为3.6 (95% CI 2.5-5.2)；戒烟者中风险相似(OR 1.0, 95% CI 0.6-1.6)。产后1年，持续戒烟者校正产后增加的体重高于不吸烟者2.4-kg (95% CI 1.6-3.1)。
   结论：戒烟与妊娠期以及产后体重的增加相关。然而，戒烟与新生儿出生体重少于第10百分位比率大幅度降低相关。
 

（刘国梁 审校）
Obstet Gynecol. 2013 Aug 5. [Epub ahead of print]

 

Effect of Smoking Cessation on Gestational and Postpartum Weight Gain and Neonatal Birth Weight.
 

Rode L, Kjærgaard H, Damm P, Ottesen B, Hegaard H.
 

Abstract
OBJECTIVE:To examine the association among smoking cessation, gestational and postpartum weight gain, and neonatal birth weight.
METHODS:We analyzed prospectively collected data from 1,774 women with term singleton pregnancies. Smoking status during pregnancy was categorized as nonsmokers, smokers, and quitters; and smoking status 1 year postpartum as nonsmokers, smokers, relapsed quitters, and sustained quitters. The association between smoking status and gestational weight gain, weight gain 1 year postpartum, and neonatal birth weight was tested by linear regression analysis, and the association between smoking status and neonatal birth weight less than the 10th percentile for gestational age and sex was tested by multivariable logistic regression analysis.
RESULTS:Gestational weight gain at 16 weeks of gestation was comparable for nonsmokers, smokers, and quitters. The adjusted mean gestational weight gain at 37 weeks of gestation was 2.0 kg (95% confidence interval [CI] 1.5-2.6) higher in quitters compared with nonsmokers. The rate of neonatal birth weight less than the 10th percentile was 21.7% among smokers, 8.0% among quitters, and 7.4% among nonsmokers. The adjusted odds ratio (OR) for birth weight less than 10th percentile was 3.6 (95% CI 2.5-5.2) in neonates born to smokers; the risk was similar for quitters (OR 1.0, 95% CI 0.6-1.6). One year after delivery, sustained quitters had a 2.4-kg (95% CI 1.6-3.1) higher adjusted postpartum weight gain than nonsmokers.
CONCLUSION:Smoking cessation is associated with gestational as well as postpartum weight gain. However, smoking cessation is associated with a substantially lower rate of neonatal birth weight less than the 10th percentile.
 

Obstet Gynecol. 2013 Aug 5. [Epub ahead of print]