哮喘联盟

   摘要
   最近的研究表明，生活在美国和韩国高海拔地区的人自杀率增加。一种可能的机制被提出，即代谢应激与缺氧有关。这种解说讨论了这一结果，也讨论了自杀比率增加和其他相关的缺氧条件（吸烟，慢性阻塞性肺病和哮喘）的关系。色氨酸羟化酶通常不会被氧和，因此轻度缺氧会降低5-羟色胺的合成。众所周知，大脑低5-羟色胺与自杀有关。因此，该解说提出和探讨了这一假设，大脑5-羟色胺合成减少与缺氧有关，这一机制可能导致在缺氧的条件下自杀。最后，提出了各种各样可以验证这一假设的研究。
 

（林江涛 审校）
J Psychiatry Neurosci. 2013 Aug 13;38(5):130002. doi: 10.1503/jpn.130002. [Epub ahead of print]

 

Elevated incidence of suicide in people living at altitude, smokers and patients with chronic obstructive pulmonary disease and asthma: possible role of hypoxia causing decreased serotonin synthesis.
 

Young SN.
 

Abstract
Recent research indicates that suicide rates are elevated in those living at higher altitudes in both the United States and South Korea. A possible mechanism that was proposed is metabolic stress associated with hypoxia. This commentary discusses these results, and also the association between elevated suicide rates and other conditions associated with hypoxia (smoking, chronic obstructive pulmonary disease and asthma). Tryptophan hydroxylase may not normally be saturated with oxygen, so mild hypoxia would decrease serotonin synthesis. Low brain serotonin is known to be associated with suicide. Thus, the commentary proposes and discusses the hypothesis that decreased brain serotonin synthesis associated with hypoxia is a mechanism that may contribute to suicide in conditions causing hypoxia. Finally the commentary proposes various studies that could test aspects of this hypothesis.

J Psychiatry Neurosci. 2013 Aug 13;38(5):130002. doi: 10.1503/jpn.130002. [Epub ahead of print]